Intratumour heterogeneity, from hypothesis to the clinic.

Br J Cancer

Yale Cancer Center, Yale School of Medicine, 333 Cedar St., PO Box 208032, New Haven, CT, 05620, USA.

Published: February 2023

Recent technological advances uncovered intricate biological processes underlying intratumor heterogeneity with clinical implications. These insights led to novel biomarkers for immunotherapies, justified serial tumour biopsies for therapeutic target profiling, inspired new treatment strategies, and ultimately might yield novel therapeutics that target clonal interdependence.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9938204PMC
http://dx.doi.org/10.1038/s41416-022-02008-wDOI Listing

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