Objectives: To evaluate the feasibility of narrow-field supracricoid partial laryngectomy with cricohyoidoepiglottopexy (NF-SCPL-CHEP).
Methods: Between 2019 and 2020, five patients with glottic cancers underwent NF-SCPL-CHEP. The mean durations of surgical drains, tracheostomy canula, and nasogastric tube use were evaluated. Length of stay following NF-SCPL-CHEP was compared with that of our open SCPL historical controls. A case summary is provided for the first patients, with detailed information about postoperative management and function.
Results: All five patients achieved uneventful postoperative recoveries without major complications. The average time for surgical drains, tracheostomy canula, and nasogastric tube use were 2, 15, and 46 days, respectively. The mean overall hospitalization period was 36 days for NF-SCPL-CHEP patients. The mean period of hospitalization based on our early experiences between 1997 and 2005 with classical open SCPL was 72 days. All patients were fully functional and local recurrences or distant metastases were not encountered during a mean observation period of 39 months.
Conclusions: NF-SCPL-CHEP with 6 cm cervical access appeared technically feasible and oncologically sound in this initial clinical experience. An extra 2 cm incision, which enabled lateral neck dissection, was not felt to detract from the overall minimally invasive basis of NF-SCPL-CHEP. The clinical results were encouraging with limited complications and predictable postoperative recovery. The length of stay for patients undergoing NF-SCPL was half that of open SCPL historical controls. Less damages to local circulation may associate with the positive influences. Further study with a large patient sample across multiple institutions are needed to carefully evaluate long-term functional and oncological outcomes.
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http://dx.doi.org/10.1016/j.anl.2022.09.011 | DOI Listing |
New Phytol
July 2024
Key Laboratory of Bio-resource and Eco-environment of Ministry of Education, College of Life Sciences, Sichuan University, Chengdu, 610064, China.
The metabolism of massively accumulated chlorogenic acid is crucial for the successful germination of purple coneflower (Echinacea purpurea (L.) Menoch). A serine carboxypeptidase-like (SCPL) acyltransferase (chicoric acid synthase, CAS) utilizes chlorogenic acid to produce chicoric acid during germination.
View Article and Find Full Text PDFAuris Nasus Larynx
June 2023
Division of Head and Neck Surgery, University of California San Diego, La Jolla, California, USA.
Objectives: To evaluate the feasibility of narrow-field supracricoid partial laryngectomy with cricohyoidoepiglottopexy (NF-SCPL-CHEP).
Methods: Between 2019 and 2020, five patients with glottic cancers underwent NF-SCPL-CHEP. The mean durations of surgical drains, tracheostomy canula, and nasogastric tube use were evaluated.
J Minim Access Surg
January 2021
Department of Otorhinolaryngology and Head and Neck, Marly Clinic, Bogotá DC; Department of Otorhinolaryngology, Section of Laryngology, Children's University Hospital of San José, University Foundation of Health Sciences, Bogotá, Colombia.
Spindle cell/pleomorphic lipoma (SC/PL) is a subcutaneous mass usually localised on nape, shoulder or upper back. It is a benign lipogenic tumour composed of primitive CD34-positive spindle cells, floret-like multinucleated giant cells and mature adipocytes. Complete surgical excision is the optimal treatment.
View Article and Find Full Text PDFAnn Otol Rhinol Laryngol
March 2020
Department of Otolaryngology-Head and Neck Surgery, Yokohama City University, Yokohama, Kanagawa, Japan.
Objectives: The hybrid supracricoid partial laryngectomy with cricohyoidoepiglottopexy (SCPL-CHEP, that is, open partial horizontal laryngectomies OPHL Type IIa) has been described using a flexible next generation robotic surgical platform for manipulation. We sought to evaluate the feasibility of performing this procedure using endoscopic transoral (EndoT) surgical techniques without robotics.
Methods: Preclinical cadaveric study using two human cadavers.
Laryngoscope
September 2019
Division of Head and Neck Surgery, University of California San Diego, San Diego, California, U.S.A.
Objectives/hypothesis: To describe a hybrid supracricoid partial laryngectomy with cricohyoidoepiglottopexy (hybrid SCPL-CHEP) combining limited transcervical and transoral robotic approaches.
Study Design: Preclinical cadaveric study.
Methods: Using six human cadavers in a series of three preclinical laboratories (July 2016-February 2018), we developed a novel hybrid technique for SCPL-CHEP.
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