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Evaluation of drug interactions of saxagliptin with sildenafil in healthy volunteers. | LitMetric
Purpose : The purpose of this study is to investigate the effect of sildenafil a CYP3A4 substrate and inhibitor on the pharmacokinetics and safety of saxagliptin.Methods : Eighteen healthy volunteers were recruited in sequential; single-center study to determine pharmacokinetic parameters of saxagliptin and sildenafil, and (AUC), (AUC); C; t; t, k; k were measured using validated LC-MS/MS method. Therapeutic doses were given as follows: Sildenafil 50 mg single dose on day one, then washout period from day two till day eight. Saxagliptin 5 mg once/day was given from day 9 till day 12; then on day 13, the two drugs were co-administered. Blood samples for pharmacokinetic analysis were collected on days 1 and 13 for sildenafil and on days 12 and 13 for saxagliptin.Results : Saxagliptin ratios of T/R and 90% CI were 132.1% (122.7-142.3) for AUC, and 167.6% (154.6-181.8) for C. On the other hand, sildenafil pharmacokinetics were not affected. G changed from 93.7 mg/dl to 95.6 mg/dl (P > 0.001) and AUC from 512.8 ng.h/ml to 532.75 ng.h/ml (P > 0.001) after co-administration of both drugs.Conclusion : Sildenafil significantly affected the pharmacokinetic parameters of saxagliptin when co-administered.Registration : This trial was registered at clinicaltrials.gov under identifier number: [NCT04170790] in November 2019.
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