A new water-soluble xenon host system with great promise for the Xe NMR-based biosensing approach is presented: the -cryptophane-222-hexacarboxylate. It compares favorably with its already known diastereomer, on the one hand, and with cucurbit[6]uril, on the other hand, in particular in terms of xenon binding constant and xenon in-out exchange, a key parameter for the efficiency of the most sensitive HyperCEST method.
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Phys Chem Chem Phys
October 2022
NIMBE, CEA, CNRS, Université de Paris Saclay, CEA Saclay, 91191 Gif-sur-Yvette, France.
A new water-soluble xenon host system with great promise for the Xe NMR-based biosensing approach is presented: the -cryptophane-222-hexacarboxylate. It compares favorably with its already known diastereomer, on the one hand, and with cucurbit[6]uril, on the other hand, in particular in terms of xenon binding constant and xenon in-out exchange, a key parameter for the efficiency of the most sensitive HyperCEST method.
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Laboratoire de Chimie, Ens de Lyon, CNRS UMR 5182, Lyon, France.
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Macrocyclic host structures for generating transiently bound Xe have been used in various ultra-sensitive NMR and MRI applications for molecular sensing of biochemical analytes. They are based on hyperpolarized nuclei chemical exchange saturation transfer (Hyper-CEST). Here, we tested a set of water-soluble pillar[5]arenes with different counterions in order to compare their potential contrast agent abilities with that of cryptophane-A (CrA), the most widely used host for such purposes.
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