AI Article Synopsis
- The study investigates how antibiotic resistance in stomach bacteria varies with the severity of atrophic gastritis in patients undergoing gastrointestinal endoscopy.
- It involved 110 patients, categorizing them based on the level of atrophy, and testing bacterial strains for resistance to various antibiotics using standard methods.
- The results showed notable resistance rates to clarithromycin, metronidazole, and levofloxacin, with significant differences in resistance observed between antrum and corpus biopsies, especially as gastritis severity increased.
Article Abstract
Background: Antibiotic susceptibility of to antibiotics may vary among different niches of the stomach. The progression of chronic gastritis to atrophy changes intragastric physiology that may influence selection of resistant strains.
Aim: To study the antibiotic resistance of taking the severity of atrophic gastritis in antrum and corpus into account.
Methods: -positive patients ( = 110, = 32, mean age 52.6 ± 13.9 years) without prior eradication undergoing upper gastrointestinal (GI) endoscopy for dyspeptic symptoms were included in a prospective study. Patients were stratified into three groups depending on the grade of atrophy: no atrophy (OLGA Stage 0), mild atrophy (OLGA Stage I-II) and moderate/severe atrophy (OLGA Stage III-IV). Two biopsies each from the antrum and the corpus and one from the angulus were taken and assessed according to the updated Sydney system. strains were isolated from antrum and corpus biopsies and tested for antibiotic susceptibility (AST) for amoxicillin, clarithromycin, metronidazole, levofloxacin, tetracycline, and rifampicin by the agar dilution methods. A Chi-square test of independence with a 95% confidence interval was used to detect differences in the proportion of patients with susceptible and resistant strains.
Results: Among 110 patients, primary clarithromycin resistance (R) was 30.0%, both in the antrum and corpus; metronidazole resistance accounted for 36.4 and 34.5% in the antrum and corpus; and levofloxacin was 19.1 and 22.7% in the antrum and corpus, respectively. Resistance rates to amoxicillin, tetracycline, and rifampicin were below 5%. Dual antibiotic resistance rate was 21.8%, and triple resistance rate was 9.1%. There was a significant difference in the resistance rate distribution in antrum ( < 0.0001) and corpus ( < 0.0001). With increasing severity of atrophy according to OLGA stages, there was a significant increase in clarithromycin-R and metronidazole-R.
Conclusion: In treatment-naïve patients, antibiotic resistance and heteroresistance were related to the severity of atrophy. The high clarithromycin resistance in atrophic gastritis suggests that antibiotic susceptibility testing should always be performed in this condition before selecting the eradication regimen.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9537355 | PMC |
| http://dx.doi.org/10.3389/fmicb.2022.938676 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Fluctuations of antimüllerian hormone, ovarian follicular reserve, and antioxidant status throughout the estrous cycle in aged mares.
Open Vet J
November 2024
Theriogenology Department, Faculty of Veterinary Medicine, Cairo University, Giza, Egypt.
Background: Senility influences fertility in women and companion animals, especially horses.
Aim: This study aimed to investigate the effect of aging in horses on the daily changes in the dominant follicle (DF) dynamics and hemodynamics, antimüllerian hormone (AMH), enzymes, antioxidants, and ovarian hormones during the estrous cycle.
Methods: Ovaries of old mares ( = 5, age >20 years) and young native mares ( = 6, age <10 years) were scanned during 6 different estrous cycles from March 2022 to August 2023 with Doppler ultrasound.
AGA Clinical Practice Update on Screening and Surveillance in Individuals at Increased Risk for Gastric Cancer in the United States: Expert Review.
Gastroenterology
December 2024
Division of Gastroenterology and Hepatology, Stanford University School of Medicine, Palo Alto, California.
Description: Gastric cancer (GC) is a leading cause of preventable cancer and mortality in certain US populations. The most impactful way to reduce GC mortality is via primary prevention, namely Helicobacter pylori eradication, and secondary prevention, namely endoscopic screening and surveillance of precancerous conditions, such as gastric intestinal metaplasia (GIM). An emerging body of evidence supports the possible impact of these strategies on GC incidence and mortality in identifiable high-risk populations in the United States.
View Article and Find Full Text PDFImportance of scattered white spots detected in the duodenum and their relationship with zonulin.
Pak J Med Sci
December 2024
Selim Demirci, Department of Gastroenterology, Dr. Abdurrahman Yurtaslan Oncology Training and Research Hospital, Ankara, Turkey.
Objective: Scattered white spots (SWS) seen in the duodenum during esophagogastroduodenoscopy are rare lesions. The histopathologic examination of SWS lesions reveals normal duodenal mucosa (ND), chronic nonspecific duodenitis, and intestinal lymphangiectasia (IL). The intestinal epithelium, through its barrier function, is responsible for tightly controlling antigen traffic from the intestinal lumen to the submucosa.
View Article and Find Full Text PDFAntral mucosa healing at long-term follow-up in patients with corpus atrophic gastritis and concomitant antral gastritis may mimic autoimmune gastritis.
Dig Liver Dis
October 2024
Department of Medical-Surgical Sciences and Translational Medicine, Sant'Andrea Hospital, Sapienza University of Rome, Italy. Electronic address:
Background And Aim: Corpus atrophic gastritis (CAG) is defined as autoimmune when the antrum is spared, representing this element a crucial diagnostic criterium of autoimmune gastritis. In contrast, CAG with concomitant antral gastritis (AG), atrophic or non-atrophic, is generally attributed to H. pylori infection.
View Article and Find Full Text PDFEndoscopic Management of Dysfunctioning Gastric Band after Sleeve Gastrectomy with the Luso-Cor Esophageal Stent.
GE Port J Gastroenterol
October 2024
Serviço de Gastrenterologia e Hepatologia, Centro Hospitalar Universitário Lisboa Norte, Lisboa, Portugal.
Article Synopsis
- A 58-year-old woman experienced complications, including regurgitation and obstruction, after her SG and subsequent ring placement, necessitating a two-step endoscopic procedure with a new Luso-Cor esophageal stent for treatment.
- After initial unsuccessful attempts to alleviate symptoms through dilatation, the stent was ultimately removed, revealing a partially eroded calibration ring, and the patient reported being asymptomatic afterward, leading to a conservative follow-up approach.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!