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Biological and residual activity of candidate larvicide formulation, SumiLarv 2MR, against an exotic invasive mosquito Anopheles stephensi Liston, 1901 (Diptera: Culicidae) in Ethiopia.
Sci Rep
January 2025
Departement of Biology, College of Natural Sciences, Jimma University, Jimma, Ethiopia.
The study evaluated the efficacy and residual activity of SumiLarv 2MR, SumiLarv 0.5G, and Abate 1SG (used as a positive control) against Anopheles stephensi larvae in Awash Subath Kilo, Afar Regional State, Ethiopia, using a semi-field experimental setup. Plastic containers with capacities of 100L and 250L were used to assess the residual efficacy of SumiLarv 2MR.
View Article and Find Full Text PDFPharmaco-Invasive Strategy With Half-Dose Tenecteplase in Patients With STEMI: Prespecified Pooled Analysis of Patients Aged ≥75 Years in STREAM-1 and 2.
Circ Cardiovasc Interv
December 2024
Canadian VIGOUR Centre (K.R.B., R.C.W., Y.Z., T.T., E.L., C.M.W., P.W.A.), University of Alberta, Edmonton, Canada.
Background: In STREAM-1 (Strategic Reperfusion Early After Myocardial Infarction), excess intracranial hemorrhage occurred in patients aged ≥75 years receiving full-dose tenecteplase as part of a pharmaco-invasive strategy, whereas no further intracranial hemorrhage occurred after halving the tenecteplase dose. In STREAM-2 (Second Strategic Reperfusion Early After Myocardial Infarction), half-dose tenecteplase was an effective and safe pharmaco-invasive strategy in older patients with ST-segment-elevation myocardial infarction presenting within <3 hours, compared with primary percutaneous coronary intervention (PCI). We prespecified evaluating the efficacy and safety of a half-dose versus full-dose pharmaco-invasive strategy and compared the half-dose pharmaco-invasive strategy to primary PCI in patients aged ≥75 years.
View Article and Find Full Text PDFOvercoming resistance in HER2-positive gastric cancer: a case report on the synergistic effect of pembrolizumab and trastuzumab.
Ann Med Surg (Lond)
December 2024
Department of Medical Oncology, Tianjin Medical University General Hospital, Tianjin, China.
Introduction: The first-line standard therapy for advanced HER2-positive gastric cancer is chemotherapy combined with trastuzumab and pembrolizumab, while pembrolizumab alone does not benefit as a monotherapy in patients with mismatch repair proficiency (pMMR). This case explores the therapeutic potential of adding pembrolizumab to patients who were resistant to trastuzumab, focusing on the synergistic effect of an immune checkmate inhibitor, combined with HER2 antibody.
Case Presentation: An 87-year-old metastatic gastric cancer patient, whose medical history was significant for intolerance to chemotherapy and had a poor status of performance.
Safety and Efficacy of Half-dose and Half-fluence Photodynamic Therapy in Chronic Central Serous Chorioretinopathy: A Systematic Review and Meta-analysis.
Am J Ophthalmol
November 2024
Department of Ophthalmology and Vision Sciences (M.M.P. and R.P.K.), University of Toronto, Toronto, Canada; John and Liz Tory Eye Centre (P.J.K., R.H.M., and R.P.K.), Sunnybrook Health Sciences Centre, Toronto, Ontario, Canada. Electronic address:
Purpose: To investigate the comparative efficacy and safety of half-dose photodynamic therapy (PDT) and half-fluence PDT in the management of chronic central serous chorioretinopathy.
Design: Systematic review and meta-analysis.
Methods: A comprehensive literature search was conducted on Ovid MEDLINE, Embase, and the Cochrane Library, covering publications from January 2000 to March 2024.
In vivo antischistosomal activity profiling and efficacy of niosomal Spirulina platensis and praziquantel combined remedy against murine Schistosoma mansoni infection.
Vet Parasitol
January 2025
Zoology Department, Faculty of Science, Beni-Suef University, Beni-Suef, Egypt.
Schistosomiasis is a serious parasite disease with a high rate of mortality and negative financial impacts in subtropical and tropical locations like Egypt. The goal of this study was to investigate the anti-schistosomal effect of Spirulina platensis (SP) and Spirulina loaded niosomes (SPN), either in the presence or absence of praziquantel (PZQ) against S. mansoni in experimentally infected mice.
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