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New insights into the role of complement system in colorectal cancer (Review).
Mol Med Rep
March 2025
Key Laboratory of Immune Microenvironment and Inflammatory Disease Research in Universities of Shandong Province, School of Basic Medical Sciences, Shandong Second Medical University, Weifang, Shandong 261053, P.R. China.
Colorectal cancer (CRC) is one of the most common cancers worldwide. With the growing understanding of immune regulation in tumors, the complement system has been recognized as a key regulator of tumor immunity. Traditionally, the complement cascade, considered an evolutionarily conserved defense mechanism against invading pathogens, has been viewed as a crucial inhibitor of tumor progression.
View Article and Find Full Text PDFBridging the Gap: The Importance of Non-technical Skills in Cardiology for Enhanced Patient Care and Team Performance.
Cureus
December 2024
Acute Medicine, Portsmouth Hospitals University NHS Trust, Portsmouth, GBR.
Cardiology, a high-acuity medical specialty, has traditionally emphasised technical expertise, often overshadowing the critical role of non-technical skills (NTS). This imbalance stems from the historical focus on procedural competence and clinical knowledge in cardiology training and practice, leaving a significant gap in the development of crucial interpersonal and cognitive abilities. However, emerging evidence highlights the significant impact of NTS on patient outcomes, team dynamics, and overall healthcare efficiency.
View Article and Find Full Text PDFProstate cancer (PCa) has high prevalence rates in men and is a leading cause of cancer-related death. Transrectal (TR) biopsy has traditionally been the gold standard for diagnosis, but transperineal (TP) biopsy is increasingly favoured due to its lower infection risk. However, debate remains regarding which method has superior cancer detection rates.
View Article and Find Full Text PDFScientific investigation on antibacterial, antioxidant, cytotoxic effects and TLC bioautography of stem bark extracts.
J Complement Integr Med
January 2025
PKFokam Institute of Excellence, Yaoundé, Cameroon.
Objectives: Hochst, belonging to the family, is known for its ethnomedicinal values, particularly in treating various diseases in Africa. This study aimed to investigate the antibacterial, antioxidant, and cytotoxic properties of stem bark extracts, with a specific focus on assessing their bioactive potential and identifying active compounds via TLC bioautography.
Methods: The antimicrobial activity was assessed using the agar well diffusion method against selected clinical strains.
Comparative antibacterial activity of clove extract against Pseudomonas aeruginosa.
BMC Complement Med Ther
January 2025
Department of Faculty of Health Sciences, American University of Madaba, Madaba, Jordan.
Pseudomonas aeruginosa is an opportunistic pathogen belonging to the γ-proteobacteria family, known to cause pneumonia linked with ventilator use and nosocomial infections. With the increasing prevalence of antibiotic-resistant bacteria, there is a pressing need to identify alternatives to conventional antibiotics. Plant-derived substances (PDSs) offer potential not only as antibacterial agents but also as modulators of antibiotic resistance.
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