AI Article Synopsis
- * Researchers found that long-term exposure to certain air pollutants was directly associated with higher levels of glucose, insulin, and indicators of insulin resistance, with certain proteins acting as mediators in these effects.
- * The findings suggest that measures like the hemoglobin glycation index (HGI) could help mitigate the negative health impacts of air pollution, providing a possible preventive strategy against pollutant-induced diabetes risks.
Article Abstract
Background: Limited evidence suggests the association of air pollutants with a series of diabetic cascades including inflammatory pathways, glucose homeostasis disorder, and prediabetes and diabetes. Subclinical strategies for preventing such pollutants-induced effects remain unknown.
Methods: We conducted a cross-sectional study in two typically air-polluted Chinese cities in 2018-2020. One-year average PM, PM, PM, SO, NO, and O were calculated according to participants' residence. GAM multinomial logistic regression was performed to investigate the association of air pollutants with diabetes status. GAM and quantile g-computation were respectively performed to investigate individual and joint effects of air pollutants on glucose homeostasis markers (glucose, insulin, HbA1c, HOMA-IR, HOMA-B and HOMA-S). Complement C3 and hsCRP were analyzed as potential mediators. The ABCS criteria and hemoglobin glycation index (HGI) were examined for their potential in preventive strategy.
Results: Long-term air pollutants exposure was associated with the risk of prediabetes [Prevalence ratio for O (PR_O) = 1.96 (95% CI: 1.24, 3.03)] and diabetes [PR_PM = 1.18 (95% CI: 1.05, 1.32); PR_PM = 1.08 (95% CI: 1.00, 1.16); PR_O = 1.35 (95% CI: 1.03, 1.74)]. PM, PM, SO or O exposure was associated with glucose-homeostasis disorder. For example, O exposure was associated with increased levels of glucose [7.67% (95% CI: 1.75, 13.92)], insulin [19.98% (95% CI: 4.53, 37.72)], HOMA-IR [34.88% (95% CI: 13.81, 59.84)], and decreased levels of HOMA-S [-25.88% (95% CI: -37.46, -12.16)]. Complement C3 and hsCRP played mediating roles in these relationships with proportion mediated ranging from 6.95% to 60.64%. Participants with HGI ≤ -0.53 were protected from the adverse effects of air pollutants.
Conclusion: Our study provides comprehensive insights into air pollutant-associated diabetic cascade and suggests subclinical preventive strategies.
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| http://dx.doi.org/10.1016/j.envres.2022.114472 | DOI Listing |
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