AI Article Synopsis
- The production of peste des petits ruminants (PPR) vaccines in Russia relies on two virus strains, "45G37/35-k" and "ARRIAH," which are of common origin.
- A full genome analysis of the PPRV/45G37/35-k strain revealed it is related to the established vaccine strain Nigeria/75/1, but with 248 nucleotide differences, suggesting it is a distinct, unrecognized strain.
- The safety and effectiveness of the Russian vaccine strains need to be thoroughly documented and submitted to the World Organization for Animal Health (WOAH) before they can be distributed widely.
Article Abstract
Production of peste des petits ruminants (PPR) vaccines in Russia is based on two attenuated virus strains ("45G37/35-k" and "ARRIAH") of common origin. Here, the identity of the strain PPRV/45G37/35-k was investigated using a full genome, Illumina deep sequencing approach. Phylogenomic analysis showed that PPRV/45G37/35-k belongs to the same lineage as the widely used PPRV vaccine strain Nigeria/75/1 (lineage II). However, 248 nucleotide differences separate the genomes of these vaccine strains, indicating that the PPRV vaccine strains produced in Russia are new strains not yet recognised by the World Organization for Animal Health (WOAH). Detailed information on the safety and efficacy of these vaccines should be provided to the WOAH before further national and international distribution.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9548208 | PMC |
| http://dx.doi.org/10.1186/s13567-022-01099-w | DOI Listing |
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