Dulaglutide is a frequently used GLP-1 analogue and one of the most potent antidiabetic drugs. Practical aspects of treatment with dulaglutide are presented in this article, together with new data from AWARD-11 study with higher concentrations of dulaglutide, especially the effects on diabetes control, body weight and side effects.
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An unprecedented strategy for unlocking a new and efficient functional group transfer protocol has been demonstrated to synthesize a variety of complex organic sulfoxides chemoselectively, starting from organic sulfides. The strategy of this new functional group transfer protocol is based on harnessing the potential of metalloradical-assisted intermolecular functional group transposition or 'InterGroupXfer' to replace highly sensitive and reactive high valent metal intermediates, [M=X] (X = O, NH).This sustainable functional group transfer strategy employs earth abundant iron catalyst and bench-stable and convenient-to-handle hydroxyl amine derived surrogate, operates under mild conditions in water or even under solvent free condition, exhibits broad functional group tolerance, as well as versatility of reaction scale and proceeds without the use of any precious metal catalyst or additional oxidant.
View Article and Find Full Text PDFImproved DNA recovery and STR profile development from weathered Bos taurus bones using demineralized bone slices.
J Forensic Sci
March 2025
Department of Forensic Science, Virginia Commonwealth University, Richmond, Virginia, USA.
Current processing techniques for harvesting DNA from osseous elements are destructive, and success rates vary widely. When skeletal elements are homogenized into a fine powder, endogenous DNA may be subjected to fragmentation, and the likelihood of introducing co-purified inhibitory substances to the sample increases. While a limited number of articles in the relevant literature have challenged the status quo of pulverization, powdering hard tissue samples before DNA isolation continues to be standard practice in the forensic and ancient DNA communities.
View Article and Find Full Text PDFThe Australasian Society of Parenteral and Enteral Nutrition: Consensus statements on refeeding syndrome.
Nutr Diet
March 2025
Department of Critical Care Medicine, Nutrition and Dietetics, Auckland City Hospital, Auckland, New Zealand.
Aims: This consensus statement document describes the recommendations of the Australasian Society of Parenteral and Enteral Nutrition regarding the identification and management of refeeding syndrome and refeeding syndrome risk.
Methods: An expert working group completed a review of the literature to develop recommendations for the consensus statements. Review of the drafted consensus statements was undertaken by highly experienced clinicians.
Melphalan 140 mg/m is Safe and Effective for Frail and Older Multiple Myeloma Patients With Comparable Rates of Minimal Residual Disease Negativity.
Clin Lymphoma Myeloma Leuk
February 2025
Department of Hematology and Oncology, University Hospitals Seidman Cancer Center, Cleveland, OH; Case Comprehensive Cancer Center, Case Western Reserve University, Cleveland, OH.
Background: Despite therapeutic advances, multiple myeloma (MM) remains challenging to treat effectively. High-dose melphalan (Mel200) with autologous stem cell transplantation (ASCT) is the standard treatment for transplant-eligible patients. Reduced-dose melphalan (Mel140) is an alternative for older or frail patients, yet its efficacy data remain unclear.
View Article and Find Full Text PDFA critical awareness approach to cluster hiring for academic inclusion.
J Natl Med Assoc
February 2025
Department of Neuroscience, Albert Einstein College of Medicine, 1410 Pelham Parkway South, Bronx, NY, 1046, USA; Department of Psychiatry, Montefiore Medical Center, 111 East 210th Street, Bronx, NY, 10467, USA; Department of Psychiatry, Massachusetts General Hospital, 55 Fruit Street Boston, MA, 02114, USA. Electronic address:
Minoritized groups experience interpersonal, structural, and systemic marginalization that is also perpetuated within academic institutions. This marginalization produces barriers that exclude racial/ethnic minoritized groups within academic medicine from career opportunities and advancement. Racial/ethnic minoritized faculty are often expected to take on additional labor to serve the diversity needs of the program and/or institution that are often unrecognized or undervalued in the tenure or promotion process or detract from additional responsibilities.
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