AI Article Synopsis
- * Scientists used techniques like 1D and 2D-NMR spectroscopy and high-resolution mass spectrometry to identify and understand the structure of these compounds.
- * Among the compounds tested for anti-inflammatory effects, one known as compound 15 showed significant activity by reducing LDH levels in a dose-dependent manner, with an IC value of 2.89 μM.
Article Abstract
A phytochemical investigation to obtain bioactive substances as lead compounds or agents for anti-inflammatory led to the obtainment of eleven previously undescribed clerodane diterpenoids, named caseatardies A-K (1-11), and four known clerodane diterpenoids (12-15) from the twigs and leaves of Casearia tardieuae. The structural elucidation of these clerodane diterpenoids was based on 1D and 2D-NMR spectroscopy (COSY, HSQC, HMBC and ROESY) as well as high resolution mass spectrometry (HR-ESI-MS). The relative configurations were defined by ROESY correlations. The anti-inflammatory activity of all the isolated compounds was screened and compound 15 decreased LDH level in a dose-dependent manner, showing IC value of 2.89 μM.
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| http://dx.doi.org/10.1016/j.fitote.2022.105328 | DOI Listing |
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