Anti-inflammatory effect of fucoidan isolated from fermented Sargassum fusiforme in in vitro and in vivo models.

Int J Biol Macromol

Department of Marine Life Sciences, Jeju National University, Jeju 63243, Republic of Korea; Marine Science Institute, Jeju National University, Jeju Self-Governing Province 63333, Republic of Korea. Electronic address:

Published: December 2022

Fucoidans possess potent anti-inflammatory effects. In the present study, the anti-inflammatory effect of the fucoidan (SFF-PS-F5) isolated from fermented Sargassum fusiforme was evaluated in vitro in RAW 264.7 macrophages and in vivo in zebrafish. The in vitro test results demonstrate that SFF-PS-F5 effectively inhibited nitric oxide (NO) production induced by lipopolysaccharides (LPS) in RAW 264.7 cells. SFF-PS-F5 effectively and concentration-dependently improved the viability of LPS-stimulated RAW 264.7 cells, and reduced the level of prostaglandin E, interleukin-1 beta, tumor necrosis factor-alpha, and interleukin-6. Further results display that these effects were actioned by suppressing the expression of inducible nitric oxide synthase and cyclooxygenase-2 via regulating the nuclear factor kappa-B signaling pathway. The in vivo test results indicate that SFF-PS-F5 remarkably reduced reactive oxygen species, cell death, and NO levels in LPS-treated zebrafish. These results indicate that SFF-PS-F5 could inhibit both in vitro and in vivo inflammatory responses and suggest it is a functional ingredient in the functional food and cosmetic industries.

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.ijbiomac.2022.10.005DOI Listing

Publication Analysis

Top Keywords

raw 2647
12
anti-inflammatory fucoidan
8
isolated fermented
8
fermented sargassum
8
sargassum fusiforme
8
vitro vivo
8
sff-ps-f5 effectively
8
nitric oxide
8
2647 cells
8
indicate sff-ps-f5
8

Similar Publications

The Physicochemical Parameters, Phenolic Content, and Antioxidant Activity of Honey from Stingless Bees and : A Systematic Review and Meta-Analysis.

Antioxidants (Basel)

December 2024

Departamento de Medicina y Zootecnia de Rumiantes, Facultad de Medicina Veterinaria y Zootecnia, Universidad Nacional Autónoma de México, Ciudad de México 04510, Mexico.

The most common bee species used for honey production is (), followed by stingless bees. This study included scientific articles using the PRISMA approach. A random effect model was implemented and the effect size (ES) was calculated and reported as the standardized mean difference (SMD) and raw mean difference (RMD).

View Article and Find Full Text PDF

Temporomandibular disorders (TMD) are a public health problem that affects around 12% of the global population. The treatment is based on analgesics, non-steroidal anti-inflammatory, corticosteroids, anticonvulsants, or arthrocentesis associated with hyaluronic acid-based viscosupplementation. However, the use of hyaluronic acid alone in viscosupplementation does not seem to be enough to regulate the intra-articular inflammatory process.

View Article and Find Full Text PDF

Development of Simple and Rapid Bead-Based Cytometric Immunoassays Using Superparamagnetic Hybrid Core-Shell Microparticles.

ACS Meas Sci Au

December 2024

Chemical and Optical Sensing Division, Bundesanstalt für Materialforschung und -prüfung (BAM), Richard-Willstätter-Str. 11, Berlin D-12489, Germany.

Flow cytometry-based immunoassays are valuable in biomedical research and clinical applications due to their high throughput and multianalyte capability, but their adoption in areas such as food safety and environmental monitoring is limited by long assay times and complex workflows. Rapid, simplified bead-based cytometric immunoassays are needed to make these methods viable for point-of-need applications, especially with the increasing accessibility of miniaturized cytometers. This work introduces superparamagnetic hybrid polystyrene-silica core-shell microparticles as promising alternatives to conventional polymer beads in competitive cytometric immunoassays.

View Article and Find Full Text PDF

The implementation of nanocomposite materials as electrode layers represents a potential turning point for next-generation of solid oxide cells in order to reduce the use of critical raw materials. However, the substitution of bulk electrode materials by thin films is still under debate especially due to the uncertainty about their performance and stability under operando conditions, which restricts their use in real applications. In this work, we propose a multiphase nanocomposite characterized by a highly disordered microstructure and high cationic intermixing as a result from thin-film self-assembly of a perovskite-based mixed ionic-electronic conductor (lanthanum strontium cobaltite) and a fluorite-based pure ionic conductor (samarium-doped ceria) as an oxygen electrode for reversible solid oxide cells.

View Article and Find Full Text PDF
Article Synopsis
  • The study investigates the intricate production process of Aceto Balsamico Tradizionale di Modena PDO, highlighting how raw materials and artisanal methods influence its flavors.
  • It employs advanced analytical techniques like solid-phase micro-extraction and gas chromatography to analyze the volatile compounds in vinegars from various wood barrels across different aging stages.
  • Results show some similarities in flavor profiles between vinegars aged in mulberry and cherry barrels, and those in juniper and oak, though direct connections to wood characteristics were not confirmed.
View Article and Find Full Text PDF

Want AI Summaries of new PubMed Abstracts delivered to your In-box?

Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!