AI Article Synopsis
- Semiconducting polymers can serve as effective photoacoustic imaging contrast agents due to their high extinction coefficients and long band absorption, but their nonbiodegradable nature raises biosafety concerns.
- Three degradable semiconducting polymers were synthesized by modifying their molecular structures, which improved their optical properties and allowed them to be broken down within the body.
- The study demonstrated the use of two of these polymers, DPPTz NPs and DPPQu NPs, for in vivo imaging in a mouse model of arthritis, offering a new approach to designing safer semiconducting polymers with enhanced imaging capabilities.
Article Abstract
Semiconducting polymer has a high extinction coefficient and a long band absorption and can be used as a photoacoustic imaging contrast agent. However, nonbiodegradable semiconducting polymers may cause biosafety issues due to being retained in the body. Therefore, developing degradable semiconducting polymers is necessary for in vivo imaging. Herein, we developed three degradable semiconducting polymers with unique optical properties. We adjusted the optical properties of semiconducting polymers by designing the molecular structure of semiconducting polymers. Polymers with a donor-π-acceptor structure could easily improve the optical properties through adjusting the donor or acceptor units. Through adjusting the electron-donor and -acceptor units, three diketopyrrolopyrrole derivative polymers (DPPTz, DPPQu, and DPPWu) were synthesized and converted into nanosize particles. By introducing the degradable chemical groups in the main chain structure of semiconducting polymers, diketopyrrolopyrrole polymers could be degraded by ClO. Among these nanosize particles, DPPTz NPs and DPPQu NPs were used to achieve the in vivo photoacoustic imaging of λ-carrageenan-induced arthritis mouse model. This work provides a novel design idea for the designing of red-shifted semiconducting polymer with degradable properties.
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| http://dx.doi.org/10.1021/acs.analchem.2c02906 | DOI Listing |
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