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The curious case of mitochondrial sirtuin in rewiring breast cancer metabolism: Mr Hyde or Dr Jekyll?
Biochim Biophys Acta Mol Basis Dis
January 2025
Department of Public Health Genomics, Centre for DNA Repair and Genome Stability (CDRGS), Manipal School of Life Sciences, Manipal Academy of Higher Education, Manipal 576104, Karnataka, India. Electronic address:
Mammalian sirtuins are class III histone deacetylases involved in the regulation of multiple biological processes including senescence, DNA repair, apoptosis, proliferation, caloric restriction, and metabolism. Among the mammalian sirtuins, SIRT3, SIRT4, and SIRT5 are localized in the mitochondria and collectively termed the mitochondrial sirtuins. Mitochondrial sirtuins are NAD+-dependent deacetylases that play a central role in cellular metabolism and function as epigenetic regulators by performing post-translational modification of cellular proteins.
View Article and Find Full Text PDFAn unexpected and tumultuous diagnosis of a left atrial mass.
Monaldi Arch Chest Dis
January 2025
Local Health Unit of São João, Porto.
This case presents a curious diagnosis in a young male presenting with chest pain. The first imaging tests suggested the presence of a hypovascular left atrial tumor. After cardiac magnetic resonance and the exclusion of extra-cardiac lesions, sarcoma emerged as the main diagnostic hypothesis.
View Article and Find Full Text PDFThe curious case of Cortex covers.
Cortex
January 2025
Penn Center for Neuroaesthetics, The University of Pennsylvania, United States. Electronic address:
When surgery leaves more than just scars: The curious case of gossypiboma- A case report and literature review.
Radiol Case Rep
March 2025
Nursing Department Communicable Disease Centre, Hamad Medical Corporation, Doha, Qatar.
Gossypiboma is a unique postoperative complication characterized by the presence of a surgical sponge after surgery. This condition is seldom encountered. Owing to its serious medicolegal implications it remains underreported leading to a blurred clinical spectrum.
View Article and Find Full Text PDFAn Unexpected Outcome of an Ischemic Stroke on the Reward Pathways in the Human Brain.
HCA Healthc J Med
December 2024
Del Sol Medical Center, El Paso, Texas.
Background: Addiction affects millions of people, often resulting from a complex interplay between genetic and environmental factors, and is frequently linked to mental health disorders. Many experts agree there is no cure for addiction, but there are effective treatments available. Many patients continue to succumb to addiction despite treatment.
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