AI Article Synopsis
- Sensory abnormalities are noted in both autism and schizophrenia, with trial-to-trial variability (TTV) indicating instability, mainly seen in response amplitudes.
- In a study assessing the auditory mismatch negativity (MMN), it was found that the MMN was most pronounced in autism and least in schizophrenia, with greater TTV present in both groups compared to controls.
- No significant differences were detected in inter-trial coherence (ITC), suggesting that while TTV varies in these conditions, the consistency of neural responses (ITC) remains similar across the groups.
Article Abstract
Sensory abnormalities are characteristic of autism and schizophrenia. In autism, greater trial-to-trial variability (TTV) in sensory neural responses suggest that the system is more unstable. However, these findings have only been identified in the amplitude and not in the timing of neural responses, and have not been fully explored in schizophrenia. TTV in event-related potential amplitudes and inter-trial coherence (ITC) were assessed in the auditory mismatch negativity (MMN) in autism, schizophrenia, and controls. MMN was largest in autism and smallest in schizophrenia, and TTV was greater in autism and schizophrenia compared to controls. There were no differences in ITC. Greater TTV appears to be characteristic of both autism and schizophrenia, implicating several neural mechanisms that could underlie sensory instability.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10079782 | PMC |
| http://dx.doi.org/10.1007/s10803-022-05771-0 | DOI Listing |
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