A common aspect of ribosome assembly, conserved across all domains of life, is the establishment of connections between the 5' and 3' ends of the large subunit (LSU) ribosomal RNA (rRNA) to initiate rRNA domain compaction and subunit assembly. We discuss the diverse mechanisms employed in different organisms to accomplish this important event.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/j.tibs.2022.09.003 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
A machine learned potential for investigating single crystal to single crystal transformations in complex organic molecular systems.
Chem Sci
December 2024
Key Laboratory of Precision and Intelligent Chemistry, University of Science and Technology of China Hefei Anhui 230026 China
The packing of organic molecular crystals is often dominated by weak non-covalent interactions, making their rearrangement under external stimuli challenging to understand. We investigate a pressure-induced single-crystal-to-single-crystal (SCSC) transformation between two polymorphs of 2,4,5-triiodo-1-imidazole using machine learning potentials. This process involves the rearrangement of halogen and hydrogen bonds combined with proton transfer within a complex solid-state system.
View Article and Find Full Text PDFFirst Report of Causing Anthracnose on in China.
Plant Dis
December 2024
Northeast Agricultural University, Harbin, United States;
Vicia amoena is renowned for its high protein content and nutritional value, making it significant in animal production and traditional Chinese medicine production. In July 2023, typical anthracnose symptoms were observed on V. amoena leaves in Suihua City (125°82'E, 46°22'N), Heilongjiang Province, China, affecting approximately 40% of the plants (a total of 200 plants were surveyed).
View Article and Find Full Text PDFBeyond Juul: The New Face of Underage Nicotine Addiction - A Survey of College Students.
Ther Innov Regul Sci
December 2024
Department of Regulatory and Quality Sciences, USC Alfred E. Mann School of Pharmacy and Pharmaceutical Sciences, University of Southern California, Los Angeles, USA.
Background: Youth nicotine addiction is a major public health concern in the United States. Disposable Electronic Nicotine Delivery Systems (ENDS), or disposable vapes, are commonly sought out by youth despite not having received premarket authorization from the FDA. The objective of this study was to identify factors contributing to underage consumption of disposable ENDS.
View Article and Find Full Text PDFConfronting the "Weaponization" of Genetics by Racists Online and Elsewhere.
Hastings Cent Rep
December 2024
Genomics research is regularly appropriated in social and political contexts to publicly legitimize unjust and malicious political views, policies, and actions. In recent years, there have been high-profile cases of mass shooters, public intellectuals, and political insiders using genomics findings to convince audiences that deadly force and coercive policies against racial minorities are warranted. To create a just genomics, geneticists must consider what makes their research so attractive and adaptable for the legitimization of unjust ends and what they can do to counter such appropriations.
View Article and Find Full Text PDFBending stiffness of Toxoplasma gondii actin filaments.
J Biol Chem
December 2024
Department of Molecular Biophysics and Biochemistry, Yale University, New Haven, CT 06520. Electronic address:
Article Synopsis
- Actin is crucial for the Apicomplexan parasite Toxoplasma gondii, supporting key processes like invasion and organelle inheritance, and its unique properties enable rapid treadmilling compared to vertebrate actin.
- Recent findings suggest that although T. gondii actin (TgAct1) has weaker interactions at its D-loop, this does not significantly impair its bending stiffness or stability, making it similar to vertebrate actin.
- Structural analysis shows that despite the differences at the D-loop, TgAct1 filaments maintain stabilizing features, indicating a mechanism where weak D-loop interactions affect subunit addition at the ends but not within the filament itself.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!