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A study on the effect of blue light on kidney stone formation in rats via the brain-kidney axis.
Sci Rep
January 2025
Department of Urology, Songjiang hospital affiliated to Shanghai jiaotong university school of medicine, Shanghai, China.
Kidney stones, a common urological disease, may involve the brain-kidney axis in their formation, though the specific mechanism remains unclear. This study aimed to investigate the effects of blue light on relevant metabolic indicators and oxidative stress status in rats with kidney stones through the brain-kidney axis. A rat model of kidney stones was established by administering 1% ethylene glycol and 2% ammonium chloride.
View Article and Find Full Text PDFMultiplexing Label-Free Polymeric Nanocarriers via Antipolymer Antibodies.
ACS Sens
January 2025
Centre for Advanced Imaging (CAI) and Australian Institute for Bioengineering and Nanotechnology, ARC Training Centre for Innovation in Biomedical Imaging Technology, The University of Queensland, St. Lucia, Queensland 4072, Australia.
Recent examples of immune responses directed against the synthetic polymer poly(ethylene glycol) (PEG) have led to the development of biocompatible polymers, which are viewed as promising candidates to act as surrogate materials for use in biological applications, such as hydrophilic poly(2-oxazoline)s (POx). Despite this, the characterization of critical aspects of the immune response against these emerging materials is sparse, in part because no known monoclonal antibodies (mAbs) against this family of synthetic material have been reported. To advance the understanding of such responses, we report the successful isolation and characterization of hybridoma-derived mAbs with excellent specificity for different POx species and notable selectivity for highly branched polymer architectures over linear systems.
View Article and Find Full Text PDFEngineered hydrogel biomaterials facilitate lung progenitor cell differentiation from induced pluripotent stem cells.
Am J Physiol Lung Cell Mol Physiol
January 2025
Department of Bioengineering, University of Colorado, Denver | Anschutz Medical Campus, Aurora, CO, USA.
Lung progenitor (LP) cells identified by the expression of transcription factor NK2 homeobox 1 (NKX2.1) are essential for development of all lung epithelial cell types and hold tremendous potential for pulmonary research and translational regenerative medicine applications. Here we present engineered hydrogels as a promising alternative to the naturally derived materials that are often used to differentiate human induced pluripotent stem cells (iPSCs) into LP cells.
View Article and Find Full Text PDFAryne Generation from -Triazenylarylboronic Acids Induced by 1,2-Diols and 4-Nitrophenol.
J Org Chem
January 2025
Meiji Pharmaceutical University, 2-522-1 Noshio, Kiyose, Tokyo 204-8588, Japan.
Arynes are important synthetic intermediates that are usually generated under alkaline conditions. We developed a method for generating arynes using two hydroxy compounds as activators. -Triazenylarylboronic acids generate (hetero)arynes when activated by a combination of ethylene glycol, pinacol, and -nitrophenol; these arynes then react with a range of arynophiles under slightly acidic conditions that complement the conventional basic conditions with unique chemoselectivities observed even in the presence of excess hydroxy compounds.
View Article and Find Full Text PDFEffect of polishing on the morphology of Zircaloy-4 nanostructure: formation of a novel hexagonal nanoscale pattern.
RSC Adv
January 2025
Department of Nuclear and Quantum Engineering, Korea Advanced Institute of Science and Technology (KAIST) 291 Daehak-ro, Yuseong-gu Daejeon 34141 Republic of Korea
Zircaloy-4 (Zr-4) is widely used as the cladding material in nuclear power plants (NPPs) due to its excellent corrosion resistance and low neutron absorption cross-section. Under Loss of Coolant Accident (LOCA) conditions, oxidation of Zr-4 can compromise the safety of the NPPs by accelerating hydrogen production. Therefore, enhancing the oxidation resistance of Zr-4 is a critical research focus.
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