Metabolic disorders or inborn errors of metabolism (IEMs) can have a wide range of neurodevelopmental and behavioral presentations. These can vary with age and/or management or stressors from common childhood/intercurrent illnesses/procedures/interventions. Collaborative care models such as multidisciplinary metabolic clinics or colocated models with behavioral health clinics and metabolic clinics in the same location can be valuable resources in improving long-term outcomes in patients with IEM. Psychologists' expertise using behavioral interventions, screening, or adaptive/cognitive measures can help with diagnosis, treatment adherence, school performance, family support, community resources, transition to adolescence and young adulthood using health belief concepts to improve outcomes.
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http://dx.doi.org/10.1016/j.pcl.2022.05.012 | DOI Listing |
Clin Exp Ophthalmol
March 2025
Department of Ophthalmology, New Zealand National Eye Centre, Faculty of Medical and Health Science, The University of Auckland, Auckland, New Zealand.
Corneal dystrophies are a group of predominantly rare inherited disorders. They are by definition bilateral, relatively symmetrical, and without systemic involvement, affecting corneal transparency and/or refraction. Traditional classification of corneal dystrophies is based on slit-lamp appearance, affected corneal layer and histological features.
View Article and Find Full Text PDFMetab Syndr Relat Disord
March 2025
Center for Nutrition and Health Research, National Institute of Public Health, Cuernavaca, México.
Metabolic syndrome (MetS) is a clinical construct that conglomerates risk factors interconnected with cardiovascular diseases and type 2 diabetes. More than a thousand million individuals in the world were diagnosed with MetS in 2018. Our objective was to examine the prevalence of MetS and its components among Mexican adults.
View Article and Find Full Text PDFJ Cell Mol Med
March 2025
Department of Cardiology, The Affiliated Hospital of Jiangnan University, Wuxi, Jiangsu, China.
Recent research has revealed a close association between obesity and various metabolic disorders, including renal metabolic diseases, but the mechanism is still unknown. This study explored the role of p16INK4a in obesity-related kidney fibrosis and evaluated its potential as a therapeutic target. Using wild-type (WT) mice and p16 KO mice, we fed both groups a high-fat diet (HFD) for 6 months.
View Article and Find Full Text PDFJ Surg Case Rep
March 2025
Department of General Surgery, Prince Sultan Military Medical City, Riyadh Makkah Al Mukarramah Road, As Sulimaniyah, Riyadh, 12233, Saudi Arabia.
Prurigo pigmentosa (PP) is a rare dermatological condition with an unclear, often idiopathic etiology, but recent evidence points to a potential link between the disease and metabolic changes, particularly those associated with ketosis. It typically presents as a pruritic, erythematous rash, mainly affecting the trunk and neck, and often features hyperpigmented macules and plaques. The onset of PP has been associated with various factors, including fasting, dieting, and certain metabolic disorders.
View Article and Find Full Text PDFFront Immunol
March 2025
Department of Endocrinology and Metabolism, Jiujiang Hospital of Traditional Chinese Medicine, Jiujiang, Jiangxi, China.
Post-translational modifications such as SUMOylation are crucial for the functionality and signal transduction of a diverse array of proteins. Analogous to ubiquitination, SUMOylation has garnered significant attention from researchers and has been implicated in the pathogenesis of various human diseases in recent years, such as cancer, neurological lesions, cardiovascular diseases, diabetes mellitus, and so on. The pathogenesis of diabetes, particularly type 1 and type 2 diabetes, has been closely associated with immune dysfunction, which constitutes the primary focus of this review.
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