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Molecular and spatial analysis of tertiary lymphoid structures in Sjogren's syndrome.
Nat Commun
January 2025
Rheumatology Research Group, Department of Inflammation and Ageing, College of Medicine & Health, University of Birmingham, Birmingham, UK.
Tertiary lymphoid structures play important roles in autoimmune and non-autoimmune conditions. While many of the molecular mechanisms involved in tertiary lymphoid structure formation have been identified, the cellular sources and temporal and spatial relationship remain unknown. Here we use combine single-cell RNA-sequencing, spatial transcriptomics and proteomics of minor salivary glands of patients with Sjogren's disease and Sicca Syndrome, with ex-vivo functional studies to construct a cellular and spatial map of key components involved in the formation and function of tertiary lymphoid structures.
View Article and Find Full Text PDFHistological Features of Delayed Foreign Body Granuloma With Epithelioid Histiocyte Aggregation and Eosinophilic Reaction due to Hyaluronic Acid Injection.
Case Rep Dent
December 2024
Division of Pathology, Department of Diagnostic and Therapeutic Sciences, Meikai University School of Dentistry, 1-1 Keyakidai, Sakado, Saitama 350-0283, Japan.
Dermal fillers such as hyaluronic acid (HA) have been widely used in recent years as a less surgically invasive cosmetic treatment. Although delayed foreign body granuloma may occur as a rare adverse reaction after the procedure, detailed histological reports are still limited. When occurring on the buccal mucosa of the oral cavity, the histopathology may resemble some lesions of minor salivary gland origin due to the material properties of HA.
View Article and Find Full Text PDFSalivary oxytocin and amygdalar alterations in functional neurological disorders.
Brain Commun
December 2024
Faculty of Science and Medicine, University of Fribourg, Fribourg 1700, Switzerland.
Individuals diagnosed with functional neurological disorder experience abnormal movement, gait, sensory processing or functional seizures, for which research into the pathophysiology identified psychosocial contributing factors as well as promising biomarkers. Recent pilot studies suggested that (epi-)genetic variants may act as vulnerability factors, for example, on the oxytocin pathway. This study set out to explore endogenous oxytocin hormone levels in saliva in a cohort of 59 functional neurological disorder patients and 65 healthy controls comparable in sex and age.
View Article and Find Full Text PDFNon-negligible prevalence of focal lymphocytic sialadenitis in minor salivary glands of non-Sjögren's disease individuals.
Clin Exp Rheumatol
December 2024
Department of Rheumatology and Immunology, Nanjing First Hospital, Nanjing Medical University, Nanjing, China.
Objectives: Focal lymphocytic sialadenitis (FLS) in minor salivary gland biopsy (MSGB) has long been regarded as a histologic hallmark of Sjögren's disease (SjD), but it can also occur in non-SjD individuals. This study aimed to define the prevalence of FLS in labial minor salivary glands of non-SjD individuals via both an autopsy study and a meta-analysis.
Methods: A total of 214 genotype-tissue expression (GTEx) volunteers was included in the autopsy study, and FLS in labial minor salivary gland was evaluated.
The effect of smoking on Sjögren's disease development and severity: a comprehensive literature review.
Clin Exp Rheumatol
December 2024
Institute of Inflammation and Ageing, College of Medical and Dental Sciences, University of Birmingham, and National Institute of Health Research (NIHR) Birmingham Biomedical Research Centre and Department of Rheumatology, University Hospitals Birmingham NHS Foundation Trust, Birmingham, UK.
Unlike other autoimmune diseases, little is known about the environmental risk factors for Sjögren's disease (SjD). Smoking is an important risk factor for rheumatoid arthritis but the relationship between smoking and SjD is more complex to understand. Current smoking seems to be negatively linked to SjD, whereas there is mixed data on past smoking.
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