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Rosai-Dorfman disease (RDD) is a rare benign proliferative disorder. Lymph nodes are the usual and common sites of involvement. Involvement of the extranodal site is also documented in the literature.

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Introduction: Rosai-Dorfman Disease (RDD), also known as sinus histiocytosis with massive lymphadenopathy, is an uncommon histiocytic disorder. It may be associated with autoimmune diseases, but there are few reports of concurrent ankylosing spondylitis. RDD is typically characterized by massive bilateral and painless cervical lymphadenopathy, which can also involve extranodal sites and constitutional symptoms, but rarely affect the chest cavity.

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Extranodal Rosai-Dorfman disease in the breast: a literature review from 1969 to 2023.

Cir Cir

November 2024

Departamento de Cirugía Plástica y Reconstructiva, Centro Médico Nacional "20 de noviembre," Instituto de Seguridad y Servicios Sociales de los Trabajadores del Estado.

Objective: Reviewing available literature regarding extranodal Rosai-Dorfman disease in the breast to explore the clinical characteristics of this disease, the described therapeutic options, and their outcomes.

Method: In January 2024, the PubMed, SpringerOpen, and Scopus databases were searched with the keywords "Rosai," "Dorfman," and "Breast." Forty-two studies were included in the final analysis, obtaining a total of 70 reported cases of extranodal Rosai-Dorfman disease affecting the breast.

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Extranodal Rosai-Dorfman disease involving the orbit and sinuses is well documented in the literature. However, those involving the lacrimal drainage system alone are rare. A woman presenting with Rosai-Dorfman disease involving the lacrimal drainage system, masquerading as a lacrimal sac malignancy, and its treatment is highlighted in the report described.

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Introduction And Importance: Rosai-Dorfman disease (RDD) is a rare benign histiocytic proliferative disorder characterized by painless lymph node enlargement and extranodal involvement. This disease often presents diagnostic challenges due to its variable clinical manifestations and the need for histologic confirmation.

Case Series Presentation: This case series examines five patients diagnosed with Rosai-Dorfman disease who presented with a variety of clinical manifestations.

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