AI Article Synopsis
- * GPR109A is a receptor that could be targeted to manage inflammation in the nervous system and other areas of the body.
- * The review highlights how GPR109A works, especially in conditions like Alzheimer's, Parkinson's, multiple sclerosis, stroke, and chronic pain, discussing its pharmacological properties and signaling mechanisms.
Article Abstract
Neuroinflammation plays a critical role in the pathological process of multiple neurological disorders and pathological pain conditions. GPR109A, a Gi protein-coupled receptor, has emerged as an important therapeutic target for controlling inflammation in various tissues and organs. In this review, we summarized current data about the role of GPR109A in neuroinflammation. Specifically, we focused on the pharmacological features of GPR109A and signaling pathways used by GPR109A to ameliorate neuroinflammation and symptoms in Alzheimer's disease, Parkinson's disease, multiple sclerosis, stroke, and pathological pain conditions.
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|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9700108 | PMC |
| http://dx.doi.org/10.4103/1673-5374.354514 | DOI Listing |
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