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Objective: To assess the arrhythmic safety profile of the adipose graft transposition procedure (AGTP) and its electrophysiological effects on post-myocardial infarction (MI) scar.
Background: Myocardial repair is a promising treatment for patients with MI. The AGTP is a cardiac reparative therapy that reduces infarct size and improves cardiac function. The impact of AGTP on arrhythmogenesis has not been addressed.
Methods: MI was induced in 20 swine. Contrast-enhanced magnetic resonance (ce-MRI), electrophysiological study (EPS), and left-ventricular endocardial high-density mapping were performed 15 days post-MI. Animals were randomized 1:1 to AGTP or sham-surgery group and monitored with ECG-Holter. Repeat EPS, endocardial mapping, and ce-MRI were performed 30 days post-intervention. Myocardial SERCA2, Connexin-43 (Cx43), Ryanodine receptor-2 (RyR2), and cardiac troponin-I (cTnI) gene and protein expression were evaluated.
Results: The AGTP group showed a significant reduction of the total infarct scar, border zone and dense scar mass by ce-MRI ( = 0.04), and a decreased total scar and border zone area in bipolar voltage mapping ( < 0.001). AGTP treatment significantly reduced the area of very-slow conduction velocity (<0.2 m/s) ( = 0.002), the number of deceleration zones ( = 0.029), and the area of fractionated electrograms ( = 0.005). No differences were detected in number of induced or spontaneous ventricular arrhythmias at EPS and Holter-monitoring. SERCA2, Cx43, and RyR2 gene expression were decreased in the infarct core of AGTP-treated animals ( = 0.021, = 0.018, = 0.051, respectively).
Conclusion: AGTP is a safe reparative therapy in terms of arrhythmic risk and provides additional protective effect against adverse electrophysiological remodeling in ischemic heart disease.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9530287 | PMC |
| http://dx.doi.org/10.3389/fcvm.2022.983001 | DOI Listing |
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