AI Article Synopsis
- Researchers studied a type of lung cancer called Non Small Cell Lung Cancer (NSCLC) and found that the commonly used test for a protein called PD-L1 is not very good at showing how well treatments will work, especially in patients with low levels of this protein.
- They looked at tiny particles from the blood, called EVs, in 64 patients with low PD-L1 who were treated with immune therapies, and found that those who responded better to treatment had specific markers on their EVs.
- The study suggests that measuring certain markers on these EVs could help doctors figure out which patients are more likely to benefit from immune therapies for their cancer.
Article Abstract
PD-L1 in tumor cells is the only used biomarker for anti PD1/PD-L1 immune-checkpoints inhibitors (ICI) in Non Small Cell Lung Cancer (NSCLC) patients. However, this parameter is inaccurate to predict response, especially in patients with low tumor PD-L1. Here, we evaluated circulating EVs as possible biomarkers for ICI in advanced NSCLC patients with low tumoral PD-L1. EVs were isolated from plasma of 64 PD-L1 low, ICI-treated NSCLC patients, classified either as responders (R; complete or partial response by RECIST 1.1) or non-responders (NR). EVs were characterized following MISEV guidelines and by flow cytometry. T cells from healthy donors were triggered using patients' EVs. Unsupervised statistical approach was applied to correlate EVs' and patients' features to clinical response. R-EVs showed higher levels of tetraspanins (CD9, CD81, CD63) than NR-EVs, significantly associated to better overall response rate (ORR). In multivariable analysis CD81-EVs correlated with ORR. Unsupervised analysis revealed a cluster of variables on EVs, including tetraspanins, significantly associated with ORR and improved survival. R-EVs expressed more costimulatory molecules than NR-EVs although both increased T cell proliferation and partially, activation. Tetraspanins levels on EVs could represent promising biomarkers for ICI response in NSCLC.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9530186 | PMC |
| http://dx.doi.org/10.3389/fimmu.2022.987639 | DOI Listing |
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