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Intracranial solitary fibrous tumour with rhabdomyosarcomatous differentiation: A diagnostic challenge of a rare presentation.
Int J Surg Case Rep
December 2024
Department of Pathology, Vardhman Mahavir Medical College and Safdarjung Hospital, New Delhi, India. Electronic address:
Introduction And Importance: Solitary fibrous tumors (SFTs) are rare mesenchymal neoplasms, initially described in the pleura but capable of arising in various anatomical locations, including the central nervous system. Dedifferentiation, characterized by the transformation of a low-grade tumor into a high-grade sarcoma, is an uncommon phenomenon in SFTs, especially in the intracranial region.
Case Presentation: A 31-year-old male visited the neurology outpatient department with complaints of frequent headaches, seizures, speech difficulties, and weakness on the left side of his body.
Spermatocytic tumor of testis: A case series of 26 cases elucidating unusual patterns with diagnostic and treatment dilemmas.
J Cancer Res Ther
December 2022
Department of Pathology, Tata Memorial Centre, Homi Bhabha National Institute, Mumbai, Maharashtra, India.
Background: Spermatocytic tumours are a rare subset of testicular tumours seen in elderly patients with distinct clinicopathological features and a favourable outcome. The typical presentation and characteristic histological features usually suffice for the diagnosis. Most of the cases are amenable to surgical excision.
View Article and Find Full Text PDFMalignant mixed epithelial and stromal tumor of the kidney with rhabdomyosarcomatous transformation presenting with gross hematuria.
Proc (Bayl Univ Med Cent)
July 2022
Department of Urology and Urological Oncology, Iran University of Medical Sciences, Tehran, Iran.
Malignant rhabdomyosarcoma associated with mixed epithelial and stromal tumor of the kidney (MESTK) is an exceptionally rare clinical phenomenon, with only two reported cases. Here, we describe the case of a middle-aged Middle Eastern woman with a left renal mass diagnosed as malignant MESTK with rhabdomyosarcomatous transformation. The patient initially presented with gross hematuria and was found to have a heterogenous 6.
View Article and Find Full Text PDFRhabdomyosarcomatous Transformation as a Mechanism of Resistance to Osimertinib and Savolitinib in EGFR-Mutant Lung Adenocarcinoma With After Osimertinib First-Line Treatment.
JCO Precis Oncol
October 2022
Department of Pathology, R. Professor Antonio Prudente, São Paulo, Brazil.
Inflammatory leiomyosarcoma/rhabdomyoblastic tumor: A report of two cases with novel genetic findings.
Genes Chromosomes Cancer
November 2022
Department of Pathology, Northwestern University Feinberg School of Medicine, Northwestern Memorial Hospital, Chicago, Illinois, USA.
Inflammatory leiomyosarcoma (ILMS) is a malignant neoplasm showing smooth muscle differentiation, a prominent inflammatory infiltrate, and near-haploidization. These tumors have significant pathologic and genetic overlap with the recently described "inflammatory rhabdomyoblastic tumor (IRT)," suggesting that ILMS and IRT may belong to one entity. Herein, we describe two cases of ILMS/IRT with attention to new cytogenetic and sequencing findings.
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