This review presents a comprehensive evaluation of the effectiveness of routinely delivered psychological therapies across inpatient, outpatient and University-based clinics. This was a pre-registered systematic-review of studies meeting pre-specified inclusion criteria (CRD42020175235). Eligible studies were searched in three databases: MEDLINE, CINAHL and PsycInfo. Pre-post treatment (uncontrolled) effect sizes were calculated and pooled using random effects meta-analysis to generate effectiveness benchmarks. Moderator analyses were used to examine sources of heterogeneity in effect sizes. Overall, 252 studies (k = 298 samples) were identified, of which 223 (k = 263 samples) provided sufficient data for inclusion in meta-analysis. Results showed large pre-post treatment effects for depression [d = 0.96, (CI 0.88-1.04), p ≤ 0.001, k = 122], anxiety [d = 0.8 (CI 0.71-0.9), p ≤ 0.001, k = 69], and other outcomes [d = 1.01 (CI 0.93-1.09), p ≤ 0.001, k = 158]. This review provides support for the effectiveness of routinely delivered psychological therapy. Effectiveness benchmarks are supplied to support service evaluations across multiple settings.
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http://dx.doi.org/10.1007/s10488-022-01225-y | DOI Listing |
Over the last decade, Hippo signaling has emerged as a major tumor-suppressing pathway. Its dysregulation is associated with abnormal expression of and -family genes. Recent works have highlighted the role of YAP1/TEAD activity in several cancers and its potential therapeutic implications.
View Article and Find Full Text PDFRisk Manag Healthc Policy
January 2025
Department of Medical Rehabilitation Science, Faculty of Applied Medical Sciences, Umm Al-Qura University-Makkah-Saudi Arabia; Cairo University, Cairo, Egypt.
Introduction: Dual tasking (DT) requires individuals to carry out two actions simultaneously, comparable to how the brain can perform a cognitive function while the body is in motion, which eventually enhances human balance. This paper aims to examine and compare the impact of DT on the risk of falling (ROF) among Saudi female students.
Methods: A cross-sectional design was used.
J Orthop
July 2025
University of Louisville, Department of Orthopaedic Surgery, United States.
Background: Traditionally, total joint arthroplasty has been performed as an inpatient procedure, sometimes requiring a hospital stay of a few days. However, outpatient total joints have gained popularity in recent years. The purpose of this study is to compare patient outcomes following an outpatient total knee arthroplasty (TKA) or a total hip arthroplasty (THA) in a hospital setting versus an ambulatory surgical center.
View Article and Find Full Text PDFData Min Knowl Discov
January 2025
CWI, Amsterdam, The Netherlands.
Missing values arise routinely in real-world sequential (string) datasets due to: (1) imprecise data measurements; (2) flexible sequence modeling, such as binding profiles of molecular sequences; or (3) the existence of confidential information in a dataset which has been deleted deliberately for privacy protection. In order to analyze such datasets, it is often important to replace each missing value, with one or more letters, in an efficient and effective way. Here we formalize this task as a combinatorial optimization problem: the set of constraints includes the of the missing value (i.
View Article and Find Full Text PDFFront Neurosci
January 2025
Neurology Associate P.C., Lincoln, NE, United States.
Introduction: As a hallmark feature of amyotrophic lateral sclerosis (ALS), bulbar involvement significantly impacts psychosocial, emotional, and physical health. A validated objective marker is however lacking to characterize and phenotype bulbar involvement, positing a major barrier to early detection, progress monitoring, and tailored care. This study aimed to bridge this gap by constructing a multiplex functional mandibular muscle network to provide a novel objective measurement tool of bulbar involvement.
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