bark and quinine in the Portuguese official pharmacopoeias (1794-2001).

bark (bark from plants of the genus with antimalarial activity) and its alkaloid quinine were widely used to treat intermittent fevers. This paper aims to quantitatively analyze the presence of bark, quinine and other bark-derived substances in the Portuguese official pharmacopoeias published between 1794 and 2001. The analysis showed that the (1876) is the Portuguese official pharmacopeia with the highest percentage of medicines containing bark (2.61%). The (1935) is the official pharmacopeia with the highest percentage of quinine-containing medicines (2.34%). Medicines made from bark are present in the Portuguese official pharmacopoeias until the (1946). Medicines made from quinine have been present in Portuguese official pharmacopoeias since the (1835).