A 27-protein signature has been proposed to predict cardiovascular disease, but its applicability in clinical decision-making remains unclear.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1126/scitranslmed.abq4810 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Mechanisms of metabolism-coupled protein modifications.
Nat Chem Biol
January 2025
Boyce Thompson Institute, Cornell University, Ithaca, NY, USA.
Intricate coupling between metabolism and protein post-translational modifications (PTMs) has emerged as a fundamental aspect of cellular regulation. Recent studies demonstrate that protein modifications can originate from diverse metabolites, and that their regulation is closely tied to the cellular metabolic state. Here we explore recently uncovered PTMs, including the concept of 'modification of a modification', as well as associated feedback and feedforward regulatory mechanisms, in which modified proteins impact not only related metabolic pathways but also other signaling cascades affecting physiology and diseases.
View Article and Find Full Text PDFPathways to Precision Medicine in Hypertrophic Cardiomyopathy: Opportunities and Challenges in Plasma Proteomics.
Circ Heart Fail
January 2025
Division of Cardiovascular Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA.
Kick-start for metabolomics in liver disease.
World J Hepatol
September 2024
Laboratory Medicine, University Hospital Marques de Valdecilla, Santander 39008, Cantabria, Spain.
It is not complicated for the clinician to diagnose a patient with advanced fibrosis or liver cirrhosis when he has already presented some decompensation of his liver disease. However, it is in the earliest stages when the patient's prognosis can be modified the most. Since liver disease is generally asymptomatic, not invasive markers are of great relevance.
View Article and Find Full Text PDFProteomics for early prenatal screening of gestational diabetes mellitus.
World J Clin Cases
September 2024
Department of Dermatology, The Second Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang 330006, Jiangxi Province, China.
In this editorial, we comment on the article by Cao . Through applying isobaric tags for relative and absolute quantification technology coupled with liquid chromatography-tandem mass spectrometry, the researchers observed significant differential expression of 47 proteins when comparing serum samples from pregnant women with gestational diabetes mellitus (GDM) to the healthy ones. GDM symptoms may involve abnormalities in inflammatory response, complement system, coagulation cascade activation, and lipid metabolism.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!