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Distribution of High-Sensitivity Cardiac Troponin and N-Terminal Pro-Brain Natriuretic Peptide in Healthy Transgender People. | LitMetric

AI Article Synopsis

  • There are notable differences in cardiac biomarkers, high-sensitivity cardiac troponin (hs-cTn) and NT-proBNP, between transgender men and women, but little research has been done on this in healthy transgender individuals without heart disease.
  • The study aimed to evaluate the levels of hs-cTn and NT-proBNP in healthier transgender people who have been on hormone therapy (testosterone or estradiol) for at least 12 months.
  • Results showed that transgender men had higher hs-cTn levels, while transgender women had elevated NT-proBNP levels, indicating that hormonal differences may influence these cardiac biomarkers similarly to cisgender populations.*

Article Abstract

Importance: Sex-specific differences in the commonly used cardiac biomarkers high-sensitivity cardiac troponin (hs-cTn) and N-terminal pro-brain natriuretic peptide (NT-proBNP) are apparent. There is an absence of medical literature delineating the concentration differences for these biomarkers in transgender individuals without cardiac disease.

Objective: To determine the distribution of hs-cTn and NT-proBNP in healthy transgender people.

Design, Setting, And Participants: In this cross-sectional prospective study, healthy transgender individuals prescribed testosterone or estradiol for 12 months or more were recruited from internal medicine and primary care clinics that specialize in transgender medical care between November 1, 2017, and July 1, 2018.

Exposures: Testosterone or estradiol for 12 months.

Main Outcomes And Measures: Concentrations for hs-cTnI (troponin I), hs-cTnT (troponin T), and NT-proBNP were measured.

Results: Transgender people prescribed testosterone (n = 79; mean [SD] age, 28.8 [7.8] years) or estrogen (n = 93; mean [SD] age, 35.1 [11.7] years) were recruited. The concentration of hs-cTn was significantly higher in transgender men relative to transgender women. For Abbott hs-cTnI levels, the median (IQR) concentration observed in transgender men and women was 0.9 (0.6-1.7) ng/L and 0.6 (0.3-1.0) ng/L, respectively. Results were similar across 2 additional hs-cTn assays. In contrast, NT-proBNP level was higher in transgender women. The median (IQR) NT-proBNP concentration was significantly higher in transgender women ( 49 [32-86] ng/L) than in transgender men (17 [13-27] ng/L).

Conclusions And Relevance: Findings of this cross-sectional study suggest that the differences in concentration for hs-cTn and NT-proBNP between transgender men and women were similar to what is observed between cisgender men and women. Sex hormones, rather than sex assigned at birth, may be a stronger driver of the observed concentration differences between healthy men and women for biomarkers of cardiac disease.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9535541PMC
http://dx.doi.org/10.1001/jamacardio.2022.3299DOI Listing

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