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Pembrolizumab-induced type 1 diabetes.
J Oncol Pharm Pract
September 2024
Division of Endocrinology, Diabetes and Metabolism, Centro Hospitalar Universitário de Santo António, Oporto, Portugal.
Introduction: Immunotherapy has a crucial role in the current treatment of multiple malignancies. Albeit described as rare, new onset autoimmune diabetes is a potentially life-threatening complication of programmed cell death-1 (PD-1) inhibitors, such as pembrolizumab, and its predisposing factors and pathological mechanism are yet to be clarified.
Case Report: We present a case of a 72-year-old man with a high-grade bladder carcinoma undergoing pembrolizumab treatment.
Preceding polydipsia/polyuria, ataxia, and dysarthria in an adult with mixed histiocytosis (Erdheim Chester disease/Langerhans cell histiocytosis).
Ann Hematol
December 2022
Division of Hematology, Uji-Tokushukai Medical Center, Uji, Kyoto, 611-0041, Japan.
Clinical features at the onset of childhood type 1 diabetes mellitus in Shenyang, China.
J Paediatr Child Health
April 2010
Department of Pediatrics, Shengjing Hospital of China Medical University, Shenyang, China.
Aim: To describe the clinical picture and laboratory features of Chinese children with newly diagnosed type 1 diabetes mellitus.
Methods: The clinical and laboratory data of a total of 203 children who presented with newly diagnosed type 1 diabetes mellitus during a 5-year period (2004-2008) were retrospectively analysed based on hospital records.
Results: There were 88 boys (43.
Frequency of ketoacidosis in newly diagnosed type 1 diabetic children.
Oman Med J
April 2010
Department of Pediatric Endocrinology, Besat Hospital, Hamadan Iran.
Objectives: Diabetic ketoacidosis (DKA) is the leading cause of morbidity and mortality in children with type 1 diabetes mellitus (TIDM). Many patients with newly diagnosed type 1 diabetes present with DKA. The aim of this study is to determine the frequency and the clinical presentation of diabetic ketoacidosis at the diagnosis of type 1 diabetes mellitus in youths in hamadan, Western Province of Iran.
View Article and Find Full Text PDFTraumatic partial hypopituitarism in a cat.
J Small Anim Pract
August 2004
Davies White Veterinary Specialists, Manor Farm Business Park, Higham Gobion, Hertfordshire.
Traumatic hypopituitarism was diagnosed in an 11-month-old male neutered cat. The presenting complaints were polydipsia, polyuria and lethargy of three months' duration. Craniocerebral trauma, as a result of a road traffic accident, had preceded the onset of clinical signs by six weeks.
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