Resveratrol (RES) is a natural polyphenol with a variety of health beneficial properties, but its application is greatly limited due to low aqueous solubility and poor bioavailability. This study aims to address these issues gliadin nanoparticles stabilized with oxidized chitin nanocrystals (O-ChNCs) as a delivery system for RES. RES-loaded gliadin nanoparticles (GRNPs) were fabricated by an antisolvent method, and their formation mechanism was elucidated using zeta-potential, FTIR, XRD, and TEM. Furthermore, the effect of O-ChNCs on the colloidal stability and bioactiveness of GRNPs was discussed. The results demonstrate that O-ChNCs are adsorbed onto the surface of GRNPs through hydrogen bonding and electrostatic interactions, leading to the enhanced absolute potential and the improved hydrophobicity of the particles, which in turn facilitates the stability of the GRNPs. Furthermore, the changes in the release profile and antioxidant activity of RES in the simulated gastric and intestinal tracts indicate that the adsorption of O-ChNCs not only delays the release of RES but also has a protective effect on the antioxidant capacity of RES. This study provides significant implications for developing stable gliadin nanoparticles as delivery vehicles for bioactive substances.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1021/acs.jafc.2c04174 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Tuning the Interfacial Deformation of Gliadin-Flaxseed Gum Complex Particles for Improving the Foam Stability.
Gels
October 2024
School of Food Science and Engineering, Wuhan Polytechnic University, Wuhan 430023, China.
Gliadin nanoparticle (GNP) is a promising foaming agent, but its application is hindered by the limited foam stability under low acidic conditions. Herein, we attempted to tune the foam stability of GNP by coating it with flaxseed gum (FG) and investigated the structure, interfacial behaviors, and foam functionality of gliadin-FG (GFG) particles at pH 4.5.
View Article and Find Full Text PDFSimultaneous detection of multiple food allergens using high signal-to-background SERS probes.
Food Chem
February 2025
State Key Laboratory of Food Nutrition and Safety, College of Food Science and Engineering, Tianjin University of Science and Technology, Tianjin 300457, China. Electronic address:
Article Synopsis
- The best way to protect those with food allergies is to avoid exposure, making accurate detection of allergens crucial.
- A new method called SERS-based sandwich immunoassay employs three types of SERS probes to simultaneously detect allergens like almonds, lactoglobulin, and gliadin.
- This method achieves high detection accuracy with low limits of detection and excellent recovery rates, ensuring effective analysis without interference from food matrix backgrounds.
In vitro sustained release modeling and antimicrobial properties of the Persian gum-based bio-nanocomposite loaded with electrosprayed gliadin containing cinnamon essential oil.
Int J Biol Macromol
December 2024
Department of Microbiology, Kerman Branch, Islamic Azad University, Kerman, Iran.
This study aimed to produce bio-nanocomposites based on Persian gum-starch using electrosprayed gliadin nanoparticles (EGNPs) containing cinnamon essential oil (CEO) to increase the shelf life of rainbow trout fillets and to model its in vitro release. The CEO with 5, 10, and 15 % w/w were loaded in the EGNPs. The EGNPs containing 10 % w/w CEO had the highest encapsulation efficiency (92.
View Article and Find Full Text PDFIn Vitro Mucoadhesive Features of Gliadin Nanoparticles Containing Thiamine Hydrochloride.
Pharmaceutics
October 2024
Department of Health Sciences, University "Magna Græcia" of Catanzaro, Campus Universitario "S Venuta", 8100 Catanzaro, Italy.
Background: Gliadins have aroused significant interest in the last decade as suitable biomaterials for food and pharmaceutical applications. In particular, the oral route is the preferred method of administration for gliadin-based formulations, due to the affinity of this biomaterial for the gut mucosa. However, up to now, this has been demonstrated only by means of in vivo or ex vivo studies.
View Article and Find Full Text PDFExploring Protein-Based Carriers in Drug Delivery: A Review.
Pharmaceutics
September 2024
Department of Pharmacy, Health and Nutritional Sciences, University of Calabria, 87036 Rende, CS, Italy.
Drug delivery systems (DDSs) represent an emerging focus for many researchers and they are becoming progressively crucial in the development of new treatments. Great attention is given to all the challenges that a drug has to overcome during its journey across barriers and tissues and all the pharmacokinetics modulations that are needed in order to reach the targeting sites. The goal of these pathways is the delivery of drugs in a controlled way, optimizing their bioavailability and minimizing side effects.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!