AI Article Synopsis
- * Twelve horses were given an intravenous dose of 22 mg/kg CET, and samples were collected at 1, 3, and 5 hours post-administration.
- * CET was effective in treating septic arthritis, pleuritis, and peritonitis caused by certain bacteria but was not effective for osteomyelitis due to low levels in bone tissue.
Article Abstract
Cephalothin (CET) concentrations in body fluids (plasma, synovial fluid, pleural fluid, peritoneal fluid, and aqueous humor) and tissue samples (bone, lung, jejunum, hoof, and subcutaneous tissue) were investigated to consider the treatment of infectious diseases in horses. CET 22 mg/kg body weight was intravenously administered to 12 horses. Samples were collected from four different horses at 1, 3, and 5 hr after administration. The CET concentration in body fluids other than aqueous humor was maintained above the MIC values of Streptococcus zooepidemicus and Staphylococcus aureus until 5 hr, but it was not maintained above that of S. aureus in bone. CET (22 mg/kg twice a day) is effective for septic arthritis, pleuritis, and peritonitis caused by gram-positive bacteria but ineffective for osteomyelitis.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9522621 | PMC |
| http://dx.doi.org/10.1294/jes.33.51 | DOI Listing |
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