AI Article Synopsis
- The study explored why individuals are increasingly accessing their polygenic risk scores (PRSs) online, focusing on their motivations and reactions.
- Participants often sought PRS information due to dissatisfaction with traditional healthcare and a desire for self-advocacy, motivated by feelings of medical distrust.
- While many found PRS results empowering, some experienced distress when the information conflicted with their personal or family health history, prompting changes in diet, supplements, and mental health strategies.
Article Abstract
The number of people accessing their own polygenic risk scores (PRSs) online is rapidly increasing, yet little is known about why people are doing this, how they react to the information, and what they do with it. We conducted a qualitative interview-based study with people who pursued PRSs through Impute.me, to explore their motivations for seeking PRS information, their emotional reactions, and actions taken in response to their results. Using interpretive description, we developed a theoretical model describing the experience of receiving PRSs in a direct-to-consumer (DTC) context. Dissatisfaction with healthcare was an important motivator for seeking PRS information. Participants described having medical concerns dismissed and experiencing medical distrust, which drove them to self-advocate for their health, which ultimately led them to seek PRSs. Polygenic risk scores were often empowering for participants but could be distressing when PRS information did not align with participants' perceptions of their personal or family histories. Behavioural changes made in response to PRS results included dietary modifications, changes in vitamin supplementation and talk-based therapy. Our data provides the first qualitative insight into how people's lived experience influence their interactions with DTC PRSs.
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|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10133316 | PMC |
| http://dx.doi.org/10.1038/s41431-022-01203-w | DOI Listing |
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