AI Article Synopsis
- Cannabidiol (CBD) shows potential as an effective treatment for epilepsy, particularly in genetically predisposed rats that exhibit two types of seizures: generalized tonic-clonic and limbic seizures.
- In the study, CBD was tested at various doses (1, 10, 50, and 100 mg/kg) and was found to significantly reduce the severity and duration of generalized tonic-clonic seizures, especially at higher doses.
- Additionally, CBD at a lower dose of 10 mg/kg was able to lessen the severity of limbic seizures in a majority of the tested rats, indicating its promise as a pharmacological option for treating different seizure types.
Article Abstract
Background: Cannabidiol (CBD) has been of rapidly growing interest in the epilepsy research field due to its antiseizure properties in preclinical models and patients with pharmacoresistant epilepsy. However, little is known about CBD effects in genetic models of epilepsies. Here we assessed CBD dose-response effects in the Genetically Epilepsy Prone Rats (GEPR-3) strain, which exhibits two types of epileptic seizures, brainstem-dependent generalized tonic-clonic seizures and limbic seizures.
Methods: GEPR-3 s were submitted to the audiogenic seizure (AGS) protocol. Acute AGS are brainstem-dependent generalized tonic-clonic, while repeated AGS (or audiogenic kindling, AK), an epileptogenic process, leads to increased AGS severity and limbic seizure expression. Therefore, two different dose-response studies were performed, one for generalized tonic-clonic seizures and the other for limbic seizures. CBD time-course effects were assessed 2, 4, and 6 h after drug injection. GEPR-3 s were submitted to within-subject tests, receiving intraperitoneal injections of CBD (1, 10, 50, 100 mg/kg/ml) and vehicle.
Results: CBD dose-dependently attenuated generalized tonic-clonic seizures in GEPR-3 s; CBD 50 and 100 mg/kg reduced brainstem-dependent seizure severity and duration. In fully kindled GEPR-3 s, CBD 10 mg/kg reduced limbic seizure severity and suppressed limbic seizure expression in 75% of animals.
Conclusions: CBD was effective against brainstem and limbic seizures in the GEPR-3 s. These results support the use of CBD treatment for epilepsies by adding new information about the pharmacological efficacy of CBD in suppressing inherited seizure susceptibility in the GEPR-3 s.
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| http://dx.doi.org/10.1007/s43440-022-00416-6 | DOI Listing |
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