The host plays an essential role in parasite transmission. The viability of the host-parasite relationship depends upon development of immune resistance and the induction of disease tolerance. Here I propose that pathogen coevolution of avirulence factors promoting host disease tolerance is an essential feature of the parasitic lifestyle.
Download full-text PDF |
Source |
---|---|
http://dx.doi.org/10.1016/j.pt.2022.09.003 | DOI Listing |
ACS Nano
January 2025
National Synchrotron Radiation Laboratory, University of Science and Technology of China, Hefei 230026, China.
Metal ions are indispensable to life, as they can serve as essential enzyme cofactors to drive fundamental biochemical reactions, yet paradoxically, excess is highly toxic. Higher-order cells have evolved functionally distinct organelles that separate and coordinate sophisticated biochemical processes to maintain cellular homeostasis upon metal ion stimuli. Here, we uncover the remodeling of subcellular architecture and organellar interactome in yeast initiated by several metal ion stimulations, relying on near-native three-dimensional imaging, cryo-soft X-ray tomography.
View Article and Find Full Text PDFJ Nat Prod
January 2025
The Ferrier Research Institute, Victoria University of Wellington, Lower Hutt, New Zealand 6012.
Phospholipids are an essential constituent of cells with all life thought to produce these compounds with either a glycerol or sphingoid moiety at their core. For the first time, we demonstrate that a thermophilic bacterium, NGM72.4, produces a third type of phospholipid, serinophospholipids, which are distinct from glycero- and sphingophospholipids by featuring a serinol backbone instead.
View Article and Find Full Text PDFPurpose: This brief report aims to summarize and discuss the methodologies of eXplainable Artificial Intelligence (XAI) and their potential applications in surgery.
Methods: We briefly introduce explainability methods, including global and individual explanatory features, methods for imaging data and time series, as well as similarity classification, and unraveled rules and laws.
Results: Given the increasing interest in artificial intelligence within the surgical field, we emphasize the critical importance of transparency and interpretability in the outputs of applied models.
Brain Topogr
January 2025
Department of Electrical Engineering, Indian Institute of Technology Roorkee, Roorkee, Uttarakhand, 247667, India.
EEG involves recording electrical activity generated by the brain through electrodes placed on the scalp. Imagined speech classification has emerged as an essential area of research in brain-computer interfaces (BCIs). Despite significant advances, accurately classifying imagined speech signals remains challenging due to their complex and non-stationary nature.
View Article and Find Full Text PDFAcc Chem Res
January 2025
The Wolfson Catalysis Centre, Department of Chemistry, University of Oxford, Oxford OX1 3QR, U.K.
ConspectusThe discovery of reversible hydrogenation using metal-free phosphoborate species in 2006 marked the official advent of frustrated Lewis pair (FLP) chemistry. This breakthrough revolutionized homogeneous catalysis approaches and paved the way for innovative catalytic strategies. The unique reactivity of FLPs is attributed to the Lewis base (LB) and Lewis acid (LA) sites either in spatial separation or in equilibrium, which actively react with molecules.
View Article and Find Full Text PDFEnter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!