Locking down SOS Mutagenesis Repression in a Dynamic Pathogen.

J Bacteriol

Department of Biology, Grinnell Collegegrid.256592.f, Grinnell, Iowa, USA.

Published: November 2022

The article "The DdrR coregulator of the Acinetobacter baumannii mutagenic DNA damage response potentiates UmuDAb repression of error-prone polymerases" in this issue of the J Bacteriol, (D. Cook, M. D. Flannigan, B. V. Candra, K. D. Compton, and J. M. Hare., J Bacteriol 204:e00165-22, 2022, https://doi.org/10.1128/jb.00165-22) reveals a more detailed understanding of the regulatory mechanism of the SOS response in Acinetobacter baumannii. This information provides novel targets for development of antimicrobial therapies against this ESKAPE pathogen and new insight into the complex regulation of the SOS stress-response.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9664947PMC
http://dx.doi.org/10.1128/jb.00220-22DOI Listing

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