AI Article Synopsis
- Three new cases of interstitial pneumopathy caused by amiodarone were reported, adding to nearly 200 existing cases in literature, highlighting the condition's relevance.
- Key characteristics of the disease include clinical, radiological, and biological features, with bronchoalveolar irrigation noted as beneficial for treatment.
- Factors that might increase risk include high doses, long-term use, other anti-arrhythmic medications, and existing lung issues, but proof is still lacking; stopping amiodarone and using steroids often leads to quick improvement.
Article Abstract
Three cases of interstitial pneumopathy secondary to amiodarone are reported, in addition to almost 200 cases previously published in the literature. The main clinical, radiological, biological and evolutive characteristics are reminded in emphasizing the advantages of bronchioalveolar irrigation. Some factors seem to be predisposing, without any definite proof however. They are: high daily dosage, long term treatment, high cumulative dose, concomitant ingestion of another anti-arrhythmic medication, especially in elderly patients, and in patients who, before any treatment, presented a decreased total pulmonary capacity and a CO transfer capacity lower than 80 p. cent of the theoretical values. Discontinuation of amiodarone and administration of steroids usually produce a rapid regression of the clinical and radiological symptoms.
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