In looking back on 2020 and 2021, this Perspective reflects on the monumental impacts of the rollout of cystic fibrosis (CF) transmembrane conductance regulator highly effective modulator therapies and the COVID-19 pandemic on the management of CF. Advancements in the clinical management of people with CF have been both enormous and rapid, and physical therapists specializing in the care of people with CF have been at the forefront of driving this evolution in care. This year sees the 30th anniversary of the UK Association of Chartered Physiotherapists in Cystic Fibrosis and, as is inevitable in reaching such milestones, thoughts have turned to origins, role, impacts, and the future. With the changing demographics of the population of people with CF after the introduction of highly effective modulator therapies, potentially with fewer secondary complications, the future role of the physical therapist who specializes in CF is in question. This Perspective reflects on and highlights the role of physical therapy within CF and provides insights into how physical therapists and respiratory therapists can evolve their roles to ensure relevance for the future.
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http://dx.doi.org/10.1093/ptj/pzac136 | DOI Listing |
Sci Rep
December 2024
School of Materials Science and Engineering, Liaocheng University, Liaocheng, 252059, Shandong, China.
The welding of titanium alloys is an important topic in today's industrial field, and the interaction between the solder and the base material is crucial for the quality of the welded parts. The structural, elastic, electronic, and thermal properties of Ti-Al-Me (Me = Cu, Fe and Ni) alloys (TAMs) with the face-centered cubic structures were investigated using plane-wave pseudo potential method in the framework of density functional theory. Based on the calculated elastic constants combined with empirical and semi-empirical formulas, physical properties including ductility/brittleness, hardness and anisotropy were calculated.
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December 2024
School of Basic Medicine, Dali University, Dali, 671003, Yunnan, China.
Resolvin D1 (RvD1) is an endogenous anti-inflammatory mediator that modulates the inflammatory response and promotes inflammation resolution. RvD1 has demonstrated neuroprotective effects in various central nervous system contexts; however, its role in the pathophysiological processes of intracerebral hemorrhage (ICH) and the potential protective mechanisms when combined with exercise rehabilitation remain unclear. A mouse model of ICH was established using collagenase, and treatment with RvD1 combined with three weeks of exercise rehabilitation significantly improved neurological deficits, muscle strength, learning, and memory in ICH mice while reducing anxiety-like behavior.
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December 2024
Clinical Nursing Teaching and Research Section, The Second XiangYa Hospital, Central South University, No139, Renmin Road, Changsha, 410011, China.
Prostate cancer, a common malignancy in older men, often requires laparoscopic radical prostatectomy, considered the gold standard treatment. However, postoperative complications can significantly impact quality of life and psychological well-being. The emergence of mobile internet health management offers a promising approach for accessible and effective post-discharge care.
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December 2024
College of Physical Science and Technology, Yangzhou University, Yangzhou, 225009, Jiangsu, China.
Nanomaterial-biomembrane interactions constitute a critical biological process in assessing the toxicity of such materials in theoretical studies. However, many investigations simplify these interactions by using membrane models containing only one or a few lipid types, deviating significantly from the complexity of real membrane compositions. In particular, cholesterol, a ubiquitous lipid essential for regulating membrane fluidity and closely linked to various diseases, is often overlooked.
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December 2024
Department of Physical Education, Guilin Medical University, Guilin, 541004, Guangxi, China.
The application of the Internet combined with extracurricular running exercise plays an important role in promoting the reform of school physical education teaching and the healthy development of students' physical fitness. 2379 students of Guilin Medical College used the Flash Campus APP for 30 weeks of running exercise during the school period, and the Wilcoxon test and t-test were used to statistically test the data of 50 m, standing long jump, lung capacity, seated forward bending, height, and body weight; men's pull-ups, 1,000 m; and women's sit-ups, 800 m pre- and post-tests. The Z/t values of men's 50 m, standing long jump, pull-ups, and lung capacity; women's 50 m running, standing long jump, sit-ups, lung capacity, and sitting prone flexion after extracurricular running exercise were - 3.
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