This study aimed to perform an association analysis of the full transcriptome in Bmp5 short-ear mice during the development of the external ear in mouse embryos using advanced sequencing techniques. To understand the changes in gene regulation and expression of BMP5 gene mutations involved in the external ear embryonic development of mice, external ear tissues of mouse embryos developed to E15.5 and E17.5 were obtained using a BMP5 short-ear mouse model. The association analysis of the full transcriptome mainly involved the analysis of lncRNA and mRNA associations, the analysis of lncRNA and miRNA associations, the analysis of miRNA and mRNA associations, the analysis of circRNA and mRNA associations and circRNA, miRNA, and mRNA associations. The results showed that regulation of the full transcriptome is associated with external ear development in BMP5 short-ear mouse embryos, and some key regulatory changes in full transcriptome after BMP5 gene point mutation are different. This study will provide a new clue to investigate the mechanism underlying the regulation of mouse external ear development by the full transcriptome.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1097/SCS.0000000000009031 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Toward improved auricle reconstruction: The role of FDM 3D printing with PCL and TPU materials.
Biomater Adv
January 2025
Department of Chemistry, Materials and Chemical Engineering G. Natta, Politecnico di Milano, Piazza Leonardo Da Vinci 32, Milan, Italy; Local Unit Politecnico di Milano, Milan, Italy. Electronic address:
Microtia, along with trauma, represents one of the main causes of external ear malformation. Different clinical techniques were developed for the reconstruction of the auricle, but they all have some drawbacks. This work is focused on the development of an innovative 3D porous scaffold, printed by Fused Deposition Modelling (FDM) and based on laser-scanned images of the healthy contralateral ear of the patient.
View Article and Find Full Text PDFPost-surgical changes in wideband absorbance in paediatric cochlear implant users after mastoidectomy and posterior tympanotomy.
Acta Otolaryngol
January 2025
Department of Audiology and Prevention of Communication Disorders, All India Institute of Speech and Hearing, Mysuru, Karnataka, India.
Background: Although Cochlear implantation (CI) is effective in restoring hearing for children with severe-to-profound sensorineural hearing loss, it may influence the middle ear mechanics, potentially causing an air-bone gap and altering middle ear stiffness, which is not detected by traditional 226 Hz tympanometry.
Aims/objectives: To investigate the effect of mastoidectomy posterior tympanotomy (MPTA) on wideband absorbance (WBA) in children with CI.
Materials And Methods: The study included 20 normal-hearing children (normal group) and 10 children with CIs who underwent MPTA (CI-MPTA group), aged 3-10 years.
Vaginal colonization and vertical transmission of Candida species: prevalence and associated factors among pregnant women and their neonates at public health facilities of Northeast Ethiopia.
BMC Pregnancy Childbirth
January 2025
Department of Medical Laboratory Sciences, College of Medicine and Health Sciences, Bahir Dar University, Bahir Dar, Ethiopia.
Background: Vaginal colonization by Candida can lead to vulvovaginal candidiasis, which is the second most prevalent vaginal condition globally. It is frequently associated with sepsis and adverse neonatal outcomes in pregnant women. This issue is worsening in Sub-Saharan Africa, including Ethiopia.
View Article and Find Full Text PDFA case of acute labyrinthitis due to intra-aural tick infestation: a case report.
J Med Case Rep
January 2025
B.P. Koirala Institute of Health Sciences, Dharan, Nepal.
Background: Intra-aural tick infestations, though uncommon, pose a serious clinical challenge owing to the risk of acute labyrinthitis-an inflammatory condition of the inner ear. This inflammation can lead to severe complications such as sensorineural hearing loss, vertigo, and facial nerve palsy. Prompt recognition and management are crucial to prevent these adverse outcomes.
View Article and Find Full Text PDFOptimal Position and Orientation of an Ossicular Accelerometer for Human Auditory Prostheses.
Sensors (Basel)
December 2024
Department of Mechanical Engineering, University of Michigan, 2350 Hayward St., Ann Arbor, MI 48109, USA.
In this study, a method for determining the optimal location and orientation of an implantable piezoelectric accelerometer on the short process of the incus is presented. The accelerometer is intended to be used as a replacement for an external microphone to enable totally implantable auditory prostheses. The optimal orientation of the sensor and the best attachment point are determined based on two criteria-maximum pressure sensitivity sum and minimum loudness level sum.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!