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Decoding Multiple Antibody Positivity: Lessons from Paraneoplastic Sensory Ataxia.
Ann Indian Acad Neurol
September 2024
Department of Neurology, All India Institute of Medical Sciences, New Delhi, India.
Article Synopsis
- * Diagnosis is confirmed by detecting antibodies in blood or cerebrospinal fluid, with immunoblot findings needing confirmation through immunofluorescence.
- * A rare case of sensory neuronopathy showed multiple antibody positivity, highlighting how facial movement issues can indicate immune-mediated neurologic syndromes.
Beyond paraneoplastic neurological syndromes: Anti-neuronal antibodies in neuropsychiatric systemic lupus erythematosus.
Lupus
October 2024
Department of Clinical Immunology and Rheumatology, Christian Medical College, Vellore, India.
Introduction: Anti-neuronal antibodies target antigens produced by tumour cells and cells of nervous system. These antibodies are formed as a result of autoimmune response elicited by the underlying malignancy, when proteins restricted to immune privileged neurons are presented by the tumour. Previous studies have shown presence of anti-neuronal antibodies in systemic lupus erythematosus and neuropsychiatric lupus (NPSLE) but information on individual antibodies and their pathogenic role is lacking.
View Article and Find Full Text PDF[A case of Stiff-person syndrome with muscle tonicity of the extremities and neck after use of Dulvalumab for lung adenocarcinoma].
Rinsho Shinkeigaku
March 2024
Department of Neurology, Hakodate Municipal Hospital.
A 74-year-old woman taking dulvalumab for lung adenocarcinoma developed muscle tonicity in the extremities and trunk. Painful paroxysmal muscle spasms with profuse sweating were frequently observed, and surface electromyography showed simultaneous contraction of the active and antagonist muscles. Blood tests were strongly positive for anti-amphiphysin antibodies, and stiff-person syndrome (SPS) was diagnosed.
View Article and Find Full Text PDFBreast cancer's hidden partner: meningoencephalitis as a paraneoplastic revelation: a rare presentation of invasive ductal carcinoma of breast: a case report.
Ann Med Surg (Lond)
January 2024
Physiology, Rawalpindi Medical University, Rawalpindi, Punjab.
Introduction And Importance: Paraneoplastic neurologic syndromes encompass a group of neurologic disorders arising from pathological processes unrelated to metastasis, metabolic disturbances, infections, coagulopathy, or treatment-related side effects. These syndromes can affect various regions of the nervous system, resulting in diverse clinical manifestations.
Case Presentation: The authors present a rare case of anti-amphiphysin-associated meningoencephalitis in a South Asian Pakistani woman.
"Hot Cross Bun" Sign in a Patient with Glutamic Acid Decarboxylase 65-KDa Isoform Associated Cerebellar Ataxia: Case Report and Review of the Literature.
Cerebellum
June 2024
Department of Neurology, Cheeloo College of Medicine, Qilu Hospital of Shandong Univeristy, Jinan, 250012, Shandong, China.
The "hot cross bun" sign (HCBs) is a cruciform hyperintensity on T2-weighted imaging within the pons initially found in patients diagnosed as multiple system atrophy. However, recent findings have broadened the disease spectrum presented with HCBs. Here is a case report at an academic medical center.
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