AI Article Synopsis
- Corticosteroids (CSs) are commonly used in cancer treatment, effective for inducing cell death in blood cancers and managing allergic reactions or treatment-related symptoms.
- Despite their benefits for patients and healthcare providers, CSs can cause potential adverse effects during and after treatment, warranting careful use in clinical settings.
- The article reviews expert opinions on CSs, including their mechanisms, therapeutic uses, and side effects, aiming to clarify existing uncertainties around their use in oncology.
Article Abstract
Corticosteroids (CSs) are widely used in oncology, presenting several different indications. They are useful for induction of apoptosis in hematological neoplasms, for management of anaphylaxis and cytokine release/hypersensitivity reaction and for the symptomatic treatment of many tumour- and treatment-related complications. If the employment of CSs in the oncological setting results in several benefits for patients and satisfaction for clinicians, on the other hand, many potential adverse events (AEs), both during treatment and after withdrawal of CSs, as well as the duality of the effects of these compounds in oncology, recommend being cautious in clinical practice. To date, several gray zones remain about indications, contraindications, dose, and duration of treatment. In this article, a panel of experts provides a critical review on CSs therapy in oncology, focusing on mechanisms of action and pharmacological characteristics, current and emerging therapeutic indications/contraindications, AEs related to CSs treatment, and the impact on patient outcome.
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| http://dx.doi.org/10.1016/j.critrevonc.2022.103826 | DOI Listing |
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