AI Article Synopsis

  • The study investigates the use of 18 F-FLT PET scans to analyze bone marrow activity in patients with peripheral cytopenias, specifically focusing on aplastic anemia and myelodysplastic syndromes.
  • A total of 68 patients underwent imaging and bone marrow analysis, revealing significant correlations between imaging results and the condition of their bone marrow.
  • Results indicate that this imaging technique can effectively differentiate between aplastic anemia and myelodysplastic syndromes while also helping to evaluate the severity and prognosis of these disorders.

Article Abstract

Purpose: Peripheral cytopenias are typical of blood test abnormalities associated with a variety of conditions, including aplastic anemia (AA) and myelodysplastic syndromes (MDSs). We prospectively investigated the feasibility of quantitative analysis of whole-body bone marrow activity using PET with 3'-deoxy-3'- 18 F-fluorothymidine ( 18 F-FLT) in AA and MDS.

Patients And Methods: Sixty-eight patients with cytopenia underwent 18 F-FLT PET/MRI scan, with simultaneous bone marrow aspiration and biopsy for hematopoiesis evaluation. SUVs were measured in the vertebrae (Th3, 6, and 9 and L3), bilateral iliac crests, and extremities. SUV and bone marrow pathology were compared between AA and MDS and analyzed in relation to severity of AA and prognosis of MDS.

Results: Of the 68 patients with cytopenia, 12 were diagnosed with AA, 27 with MDS, 12 with bone marrow neoplasia, 2 with myelofibrosis, and 15 with other conditions. Iliac 18 F-FLT SUVs were significantly correlated with bone marrow cell numbers and cell density ( r = 0.47, P < 0.001 and ρ = 0.65, P < 0.001, respectively). There was a significant positive correlation between iliac and vertebral SUVs in AA and MDS ( r = 0.65, P < 0.05 and r = 0.70, P < 0.001, respectively), and the slope of the regression line was significantly steeper in AA than in MDS ( P < 0.05). In AA patients, vertebral 18 F-FLT SUVs significantly decreased with disease progression, and in MDS patients, higher whole-body 18 F-FLT uptake was associated with shorter overall survival (hazards ratio, 3.18; 95% confidence interval, 1.07-9.47; P = 0.037).

Conclusions: Quantitative whole-body bone marrow imaging using 18 F-FLT PET helps distinguish AA from MDS and assess the severity of AA and prognosis of MDS.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9653112PMC
http://dx.doi.org/10.1097/RLU.0000000000004419DOI Listing

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