AI Article Synopsis
- The study aimed to evaluate how different doses and administration methods of Sulodexide impact leukocyte-endothelium interactions and tissue blood flow in a model of venous hypertension.
- After inducing venous hypertension in hamsters, they were treated with varying doses of Sulodexide or a placebo for several weeks, and key metrics like leukocyte behavior and capillary density were measured.
- The results showed that Sulodexide significantly reduced leukocyte adhesion and improved capillary density, with intramuscular injections being more effective than subcutaneous ones, all without altering venular diameter.
Article Abstract
Objectives: To assess the effects of different doses and routes of Sulodexide on leukocyte-endothelium interaction and tissue perfusion in a model of venous hypertension and low blood flow.
Methods: Six weeks after venous hypertension induction, through external iliac vein ligature male hamsters () received Sulodexide at 1, 2, or 4 mg/kg/day or saline (placebo) by subcutaneous or intramuscular routes during 2 or 4 weeks. After treatments, leukocyte rolling and adhesion, functional capillary density (FCD), and venular diameter were evaluated on the affected hindlimb.
Results: Subcutaneous and intramuscular treatments with Sulodexide after 2 and 4 weeks, significantly reduced leukocyte rolling and adhesion and increased FCD. Sulodexide did not affect venular diameter and intramuscular treatment was more effective in reducing leukocyte adhesion than the subcutaneous one.
Conclusion: This preliminary study demonstrated that Sulodexide significantly decreased leukocyte-endothelium interaction and improved tissue perfusion in hamsters subjected to venous hypertension and low blood flow.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1177/02683555221114539 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!