A microencapsulated, cell-based IL2 cytokine factory was recently developed, and the safety and efficacy of this platform in a mouse model of mesothelioma were demonstrated. This platform has the potential to overcome current challenges in the delivery of therapeutic cytokines for cancer immunotherapy. See related article by Nash et al., p. 5121.
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http://dx.doi.org/10.1158/1078-0432.CCR-22-2626 | DOI Listing |
Mater Horiz
January 2025
School of Materials Science and Engineering, National Institute for Advanced Materials, Nankai University, Tianjin, 300350, China.
The semi-hydrogenation of alkynes into alkenes rather than alkanes is of great importance in the chemical industry, and palladium-based metallic catalysts are currently employed. Unfortunately, a fairly high cost and uncontrollable over-hydrogenation impeded the application of Pd-based catalysts on a large scale. Herein, a sandwich structure single atom Pd catalyst, Z@Pd@Z, was prepared impregnation exchange and epitaxial growth methods (Z stands for ZIF-8), in which Pd single atoms were stabilized by pyrrolic N in a zeolitic imidazolate framework (ZIF-8).
View Article and Find Full Text PDFAnn Work Expo Health
January 2025
Department of Environmental Health and Engineering, Bloomberg School of Public Health, Johns Hopkins University, 615 N Wolfe St, Baltimore, MD 21205, United States.
The use of peracetic acid (PAA) as a general disinfectant has seen increasing usage in recent years, and although it is a strong irritant, exposure monitoring for PAA may often be difficult due to relatively high costs and the potential for interferences by other co-occurring chemicals such as hydrogen peroxide. These issues with exposure monitoring make modeling a potentially useful tool in exposure assessment of PAA if model parameters can be accurately determined. This study estimates the time-varying mass emission rate of PAA for use in exposure modeling by using the small spill model and examines the effect of various environmental conditions on the PAA evaporation rate, including surface roughness/substrate, general ventilation rate, and local wind speed.
View Article and Find Full Text PDFPsychol Sport Exerc
January 2025
Faculty of Sports Sciences, Urmia University, Urmia, Iran. Electronic address:
Objectives: The stereotype threat effect has captivated social and sports psychology researchers for over two decades. However, many questions remain unanswered. This research was designed to explore the spillover effects of stereotype threat in motor tasks.
View Article and Find Full Text PDFMar Pollut Bull
December 2024
Department of Oceanography, Center of Technology and Geosciences, Federal University of Pernambuco, Recife - PE, 50740-550, Brazil.
This study characterized polycyclic aromatic hydrocarbons (PAHs) in oil pellets stranded at Fernando de Noronha Archipelago, equatorial Atlantic. It also characterized PAHs dissolved/dispersed in seawater (i.e.
View Article and Find Full Text PDFEnviron Microbiol
October 2024
Department of Biological Sciences, University of Calgary, Calgary, Alberta, Canada.
The Arctic Ocean is an oligotrophic ecosystem facing escalating threats of oil spills as ship traffic increases owing to climate change-induced sea ice retreat. Biostimulation is an oil spill mitigation strategy that involves introducing bioavailable nutrients to enhance crude oil biodegradation by endemic oil-degrading microbes. For bioremediation to offer a viable response for future oil spill mitigation in extreme Arctic conditions, a better understanding of the effects of nutrient addition on Arctic marine microorganisms is needed.
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