Objective: This study evaluated the effect of maximal oxygen pulse (O P ) on patients with chronic obstructive pulmonary disease (COPD) and confirmed the predictive effect on acute exacerbations of COPD (AECOPD).
Methods: This retrospective study included 91 participants who underwent cardiopulmonary exercise testing (CPET), lung function testing, a dyspnea scale assessment, and a 3-year follow-up. The participants were divided into two groups according to the O P value. Exercise capacity, ventilatory conditions, gas exchange efficiency, and dyspnea symptoms were compared, and the correlations between O P and these indices were evaluated. The ability of O P to predict AECOPD was examined.
Results: Exercise capacity, ventilatory conditions, and gas exchange efficiency were lower, and dyspnea symptom scores were higher in the impaired O P group ( < 0.05). O P was positively correlated with forced vital capacity (FVC)%, forced expiratory volume in 1 sec (FEV )%, FEV /FVC%, anaerobic threshold (AT), work rate (WR)%, aximal oxygen uptake (V̇O )%, V̇O /kg , V̇O /kg %, WR , WR , V̇O , V̇O , and V̇ , and was negatively correlated with EqCO , and EqCO ( < 0.05). Most importantly, O P could be used to predict AECOPD, and the best cut-off value was 89.5% (area under the curve, 0.739; 95% , 0.609-0.869).
Conclusion: O P reflected exercise capacity, ventilation capacity, gas exchange capacity, and dyspnea symptoms in patients with COPD and may be an independent predictor of AECOPD.
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