Association of Serum Triglycerides and Total Cholesterol Levels with Impaired Fasting Glucose in Adults at a Tertiary Level Hospital of Bangladesh.

Impaired fasting glucose (IFG) is known as an intermediate state in the development of diabetes mellitus. It may be considered as a potential indicator for prevention of diabetes mellitus (DM) and cardiovascular diseases (CVDs). Dyslipidemia is characterized by high or low level of triglycerides and total cholesterol. It is known that, triglycerides and total cholesterol level raises in the DM patients. An endeavor was taken in this study to show the relationship of triglycerides (TG) and total cholesterol (TC) with IFG. This cross-sectional analytical study was carried out in Biochemistry Department of Sir Salimullah Medical College, Dhaka, Bangladesh from March 2018 to February 2019 on 120 subjects. The study subjects were 25-55 years of age. Subjects were classified into two groups i.e., Normal fasting glucose (NFG) group and IFG group. Oral glucose tolerance test (OGTT) was performed from the collected blood. TG and TC levels were measured from serum. TG and TC levels were higher (p<0.01) in IFG group than NFG group (185.56±10.32 mg/dl vs. 137.9±10.3 mg/dl) and (194.74±19.96 mg/dl vs. 174.59±13.20 mg/dl) respectively. Pearson's correlation analysis shows significant positive correlation of FPG with TG (r=0.278, p= <0.01) and TC (r=0.105, p= <0.05) in IFG subjects. Multiple regression analysis of the relation between Fasting plasma glucose (FPG) with TG and TC by adjustment of other factors revealed that IFG was significantly (p<0.01) associated with TG and TC. The AUROCs of TG, TC for IFG was found to be 0.819 (95% CI: 0.745 - 0.893), 0.652 (95% CI: 0.553-0.751) with accuracy of 76.67% and 63.33% respectively.