AI Article Synopsis
- * Understanding IL-17 biology is essential for creating new targeted therapies, and clinical trials have shown that IL-17 inhibitors like ixekizumab and secukinumab are effective treatments for moderate to severe psoriasis.
- * While IL-17 inhibitors provide rapid relief from psoriasis symptoms, they can increase the risk of fungal infections, highlighting the need for careful patient selection for these therapies.
Article Abstract
Introduction: Psoriasis is an inflammatory, chronic and immune-mediated disease that can affect the skin and joints. Pro-inflammatory cytokines have a dominant role in the pathogenesis of this heterogeneous disease in which the IL-23/IL-17 axis plays a crucial role. The IL-17 family is involved in numerous processes such as immune defense, intestinal disorders and diseases of the central nervous system. In psoriasis, in particular, many cytokines belonging to the IL-17 family are involved in the inflammatory cascade underlying the disease.
Areas Covered: The knowledge of the mechanisms and pathways behind psoriasis is crucial for the development of new target therapies. We focused on IL-17 biology in order to understand why biological drugs against this cytokine are an effective treatment for moderate to severe psoriasis. Clinical trials results of ixekizumab, brodalumab, secukinumab and bimekizumab have been presented.
Expert Opinion: Il-17 inhibitors are a very fast and effective treatment against psoriasis; however, fungal infections can occur during their use, due to IL-17 biological functions. Therefore, it should be mandatory to choose the right patients to treat with these monoclonal antibodies in order to have a tailored target therapy for each patient.
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| http://dx.doi.org/10.1080/17512433.2022.2130758 | DOI Listing |
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