Background: Calcium pyrophosphate dihydrate deposition disease (CPPD), or pseudogout, is an inflammatory arthritis common among elderly patients, but rarely seen in patients under the age of 40. In the rare cases presented of young patients with CPPD, genetic predisposition or related metabolic conditions were almost always identified.
Case Summary: The authors report the case of a 9-year-old boy with no past medical history who presented with acute knee pain and swelling after a cat scratch injury 5 d prior. Synovial fluid analysis identified calcium pyrophosphate dihydrate crystals. Further MRI analysis identified osteomyelitis and a small soft tissue abscess.
Conclusion: This case presents the extremely rare diagnostic finding of calcium pyrophosphate dihydrate crystals in a previously healthy pediatric patient. The presence of osteomyelitis presents a unique insight into the pathogenesis of these crystals in pediatric patients. More research needs to be done on the role of CPPD in pediatric arthritis and joint infection.
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http://dx.doi.org/10.5312/wjo.v13.i9.870 | DOI Listing |
Gout Urate Cryst Depos Dis
December 2024
Electrical and Computer Engineering Department, University of California, Los Angeles, CA 90095, USA.
Background: The gold standard for crystal arthritis diagnosis relies on the identification of either monosodium urate (MSU) or calcium pyrophosphate (CPP) crystals in synovial fluid. With the goal of enhanced crystal detection, we adapted a standard compensated polarized light microscope (CPLM) with a polarized digital camera and multi-focal depth imaging capabilities to create digital images from synovial fluid mounted on microscope slides. Using this single-shot computational polarized light microscopy (SCPLM) method, we compared rates of crystal detection and raters' preference for image.
View Article and Find Full Text PDFInt J Mol Sci
December 2024
Clinic of Nuclear Medicine Central University Emergency Military Hospital "Dr Carol Davila", 10825 Bucharest, Romania.
Amyloidosis is a rare pathology characterized by protein deposits in various organs and tissues. Cardiac amyloidosis (CA) can be caused by various protein deposits, but transthyretin amyloidosis (ATTR) and immunoglobulin light chain (AL) are the most frequent pathologies. Protein misfolding can be induced by several factors such as oxidative stress, genetic mutations, aging, chronic inflammation, and neoplastic disorders.
View Article and Find Full Text PDFRMD Open
December 2024
Division of Rheumatology, Geneva University Hospitals, Geneva, Switzerland.
Objectives: We propose and test a framework to detect disease diagnosis using a recent large language model (LLM), Meta's Llama-3-8B, on French-language electronic health record (EHR) documents. Specifically, it focuses on detecting gout ('goutte' in French), a ubiquitous French term that has multiple meanings beyond the disease. The study compares the performance of the LLM-based framework with traditional natural language processing techniques and tests its dependence on the parameter used.
View Article and Find Full Text PDFCureus
December 2024
Rheumatology Department of Lucania, "Madonna delle Grazie" Hospital, Matera, ITA.
Chondrocalcinosis, commonly associated with aging, is characterized by the deposition of calcium pyrophosphate dihydrate (CPPD) crystals in cartilage and periarticular tissues. Early-onset cases are rare and not well-documented. We report a case of a 60-year-old woman with a probable onset of CPP deposition (CPPD) disease during adolescence, presenting with inflammatory flare-ups and erosive progression following minor trauma.
View Article and Find Full Text PDFJ Pediatr Urol
December 2024
Department of Pediatrics, Faculty of Medicine, Cairo University, Cairo, Egypt. Electronic address:
Backgrounds: The pathophysiology of nephrolithiasis is complex, influenced by both environmental and genetic factors. Calcium is the most prevalent metabolite present in the stone matrix. Stimulating the basolateral calcium sensing receptor (CASR) in the renal tubules leads to an increase in claudin-14 expression, reducing paracellular calcium permeability and increasing urinary Ca excretion.
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