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Phosphorylation state of Akt in the heart during artificial deep hypothermia in Syrian hamsters.
J Vet Med Sci
December 2024
Laboratory of Veterinary Physiology, Faculty of Applied Biological Sciences, Gifu University.
Article Synopsis
- Hibernating animals can significantly lower their body temperature without damaging their organs, potentially due to active hypometabolism.
- Researchers studied the phosphorylation of Akt to see if metabolism decreases during artificial hypothermia in hamsters.
- They found that while hypothermia through adenosine A1 receptor activation decreased Akt phosphorylation significantly, anesthesia-induced hypothermia showed only partial reduction without organ damage, indicating both methods allow for regulated metabolic reduction.
Seizures Triggered by Systemic Administration of 4-Aminopyridine in Rats Lead to Acute Brain Glucose Hypometabolism, as Assessed by [F]FDG PET Neuroimaging.
Int J Mol Sci
November 2024
Unidad de Cartografía Cerebral, Instituto Pluridisciplinar, Universidad Complutense de Madrid, 28040 Madrid, Spain.
4-aminopyridine (4-AP) is a non-selective blocker of voltage-dependent K channels used to improve walking in multiple sclerosis patients, and it may be useful in the treatment of cerebellar diseases. In animal models, 4-AP is used as a convulsant agent. When administered intrahippocampally, 4-AP induces acute local glucose hypermetabolism and significant brain damage, while i.
View Article and Find Full Text PDFEpileptiform activity in brain organoids derived from patient with Glucose Transporter 1 Deficiency Syndrome.
Front Neurosci
November 2024
GliaPharm SA, Geneva, Switzerland.
Introduction: Glucose Transporter 1-Deficiency Syndrome (GLUT1-DS) is a rare genetic disorder caused by mutations in the gene encoding for GLUT1 and characterized by impaired glucose uptake in the brain. This leads to brain hypometabolism and the development of symptoms that include epilepsy, motor dysfunctions and cognitive impairment. The development of patient-specific models is a valuable tool for understanding the pathophysiology of rare genetic disorders and testing new therapeutic interventions.
View Article and Find Full Text PDFThe Art of Chilling Out: How Neurons Regulate Torpor.
Bioessays
February 2025
Division of Multicellular Circuit Dynamics, National Institute for Physiological Sciences, Okazaki, Japan.
Article Synopsis
- * In cold conditions with limited food, some of these animals enter a state called torpor, where they lower their body temperature and metabolic activity to save energy.
- * Research is ongoing to uncover the neuronal mechanisms behind torpor, particularly in mice, with recent studies highlighting progress and outlining unresolved questions and potential future research directions.
Analysis of physiological and biochemical changes and metabolic shifts during 21-Day fasting hypometabolism.
Sci Rep
November 2024
State Key Laboratory of Space Medicine, Astronaut Research and Training Center, 100094, Beijing, China.
Article Synopsis
- This study investigates the effects of a 21-day complete fasting period on healthy adults, analyzing physiological and biochemical changes, as well as metabolic adaptations.
- Thirteen volunteers demonstrated significant weight loss, decreased blood glucose, increased blood ketones, and a decline in resting energy expenditure during the fasting phase, while most physiological indicators remained stable.
- The findings suggest that prolonged fasting can be safely conducted under medical supervision, leading to metabolic adjustments without harming key bodily functions or organs, offering insights into health and survival strategies in extreme conditions.
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