AI Article Synopsis
- - The study investigates the effects of selective serotonin reuptake inhibitors (SSRIs) on semen quality and found that these medications negatively impact several sperm parameters, including normal morphology, concentration, motility, and DNA fragmentation.
- - Out of the four studies analyzed, which involved 222 male participants, significant reductions were noted in sperm morphology (-16.29 to -3.77), concentration (-43.88 to -4.18), motility (-23.46 to -0.47), and DNA fragmentation index (6.66 to 21.93), while semen volume remained unchanged.
- - The negative effects on sperm morphology and concentration were particularly evident within the first three months of SSRI use, highlighting the need
Article Abstract
Selective serotonin reuptake inhibitors (SSRIs) are widely used for a variety of diseases, and their impact on semen quality is unclear. We performed a systematic search in PubMed and Embase, and after a strict screening, we included 4 studies with a total of 222 male participants. In result, SSRIs reduced normal sperm morphology (95% CI [-16.29, -3.77], = 0.002), sperm concentration (95%CI [-43.88, -4.18], = 0.02), sperm motility (95%CI [-23.46, -0.47], = 0.04) and sperm DNA fragmentation index (DFI) (95% CI [6.66,21.93], = 0.0002), without a statistically significant effect on semen volume (95%CI [-0.75,0.65], = 0.89). Moreover, the impact on both sperm morphology and sperm concentration were observed within the 3-month period of SSRIs use. In general, our meta-analysis showed that SSRIs have a negative effect on semen quality. More larger, randomized, well-controlled clinical studies should be conducted to support our conclusion.
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Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9519136 | PMC |
| http://dx.doi.org/10.3389/fphar.2022.911489 | DOI Listing |
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