AI Article Synopsis
- Carbapenem-resistant hypervirulent Klebsiella pneumoniae (CR-hvKP) is a dangerous bacterium that causes severe infections in both healthcare and community settings, posing significant public health risks.
- The evolution of CR-hvKP involves complex mechanisms, including the transfer of plasmids that carry genes for both hypervirulence and carbapenem resistance.
- This review discusses these evolutionary processes and highlights the current prevalence of CR-hvKP in the population.
Article Abstract
Carbapenem-resistant hypervirulent (CR-hvKP), a type of (KP) that exhibits hypervirulence and carbapenem resistance phenotypes, can cause severe infections, both hospital- and community-acquired infections. CR-hvKP has brought great challenges to global public health and is associated with significant morbidity and mortality. There are many mechanisms responsible for the evolution of the hypervirulence and carbapenem resistance phenotypes, such as the horizontal transfer of the plasmid carrying the carbapenem resistance gene to hypervirulent (hvKP) or carbapenemase-producing (CRKP) acquiring a hypervirulence plasmid carrying a virulence-encoding gene. Notably, KP can evolve into CR-hvKP by acquiring a hybrid plasmid carrying both the carbapenem resistance and hypervirulence genes. In this review, we summarize the evolutionary mechanisms of resistance and plasmid-borne virulence as well as the prevalence of CR-hvKP.
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Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9524375 | PMC |
| http://dx.doi.org/10.3389/fmicb.2022.1003783 | DOI Listing |
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